Related Experiment Video
Updated: Jan 30, 2026

Three Different Protocols of Corneal Collagen Crosslinking in Keratoconus: Conventional, Accelerated and Iontophoresis
Published on: November 12, 2015
First experience with Oasis Collagen SOFT SHIELD® for epithelial defect after corneal cross-linking
Ivo Guber1,2, Ciara Bergin3, Shruti Malde4
1Queen Victoria Hospital, NHS Foundation Trust, East Grinstead, West Sussex, UK. ivo.guber@augenchirurgie.ch.
Dissolving collagen contact lenses offer a safe and effective alternative to traditional bandage contact lenses for post-corneal cross-linking (CXL) care. These lenses promote healing of epithelial defects and improve patient comfort without adverse effects.
Area of Science:
- Ophthalmology
- Biomaterials Science
Background:
- Investigating dissolving collagen contact lenses as a bandage for post-keratoconus corneal cross-linking (CXL) epithelial defects.
- Evaluating their efficacy as an alternative to standard bandage contact lenses.
Discussion:
- Collagen SOFT SHIELD® dissolved completely by day 4 post-intervention.
- Epithelial defects healed in most patients by day 4 and all by month 1.
- Minimal corneal haze and no adverse effects like infection were observed.
Key Insights:
- Collagen SOFT SHIELD® demonstrated complete dissolution within 4 days.
- Rapid re-epithelialization was observed, with all defects closed by 1 month.
- The collagen shield was a safe and effective alternative, improving patient comfort.
Outlook:
- Potential for improved patient outcomes in managing post-CXL epithelial defects.
- Further research into dissolving biomaterials for ocular surface applications.
- Applicable in cases where bandage contact lens removal poses challenges.
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