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Several factors can increase the risk of cancer in an individual. About 50% of cancer cases can be prevented by adopting a healthy lifestyle, regular exercise, eating healthy, and following a modest cancer prevention diet. Epidemiological studies have consistently shown that populations with vegetable and fruit-rich diets have reduced the incidence of cancer. On the other hand, populations who have a diet rich in animal fat, red meat, junk food, or high calories are predisposed to cancer.
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Preventing and Treating Colic.

Flavia Indrio1, Vanessa Nadia Dargenio2, Paola Giordano2

  • 1Department of Pediatrics, Section of Gastroenterology and Nutrition, "Aldo Moro" University of Bari, Ospedale Pediatrico Giovanni XXIII, Bari, Italy. Flaviaindrio1@gmail.com.

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This summary is machine-generated.

Probiotics show promise for managing infantile colic, a common infant issue. Further research is needed to confirm their effectiveness and optimal use in preventing future gastrointestinal problems.

Keywords:
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Area of Science:

  • Gastroenterology
  • Pediatrics
  • Microbiome research

Background:

  • Infantile colic is a frequent, distressing functional gastrointestinal disorder in infants (1-4 months).
  • It presents as prolonged, inconsolable crying and agitation with diverse causes, including feeding, parental factors, and gut issues.
  • While generally benign, colic causes significant parental anxiety and medical consultations.

Purpose of the Study:

  • To explore the potential role of probiotics in managing infantile colic.
  • To understand how probiotics might influence the gut microbiota and gut-brain axis in colicky infants.
  • To highlight the need for further research on specific probiotic formulations for colic prevention and treatment.

Main Methods:

  • Review of existing literature on infantile colic and probiotic interventions.
  • Analysis of proposed mechanisms of probiotic action on the infant gut.
  • Identification of knowledge gaps regarding probiotic pharmacodynamics and pharmacokinetics.

Main Results:

  • Probiotics may modulate the intestinal microbiota, potentially restoring homeostasis.
  • Administration of probiotics may influence gut permeability, peristalsis, and the gut-brain axis.
  • Probiotics might inhibit hypersensitivity pathways implicated in colic.

Conclusions:

  • Probiotics represent a promising avenue for developing preventive and therapeutic strategies for infantile colic.
  • Specific probiotic formulations require further investigation for efficacy and safety.
  • Early probiotic administration could potentially prevent later pain-related functional gastrointestinal disorders.