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Related Experiment Video

Updated: Jan 30, 2026

Capturing Representative Hand Use at Home Using Egocentric Video in Individuals with Upper Limb Impairment
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Can Postbiotics Represent a New Strategy for NEC?

Fabio Mosca1, Maria Lorella Gianni2, Maria Rescigno3

  • 1Fondazione I.R.C.C.S. Ca' Granda Ospedale Maggiore Policlinico, Neonatal Intensive Care Unit, Department of Clinical Science and Community Health, University of Milan, Milan, Italy. fabio.mosca@unimi.it.

Advances in Experimental Medicine and Biology
|January 19, 2019
PubMed
Summary
This summary is machine-generated.

Postbiotics, which are bacterial by-products, show promise for preventing necrotizing enterocolitis in preterm infants. Further research is needed to confirm their efficacy and determine optimal treatment protocols.

Keywords:
MicrobiotaNecrotizing enterocolitisPostbioticsPreventive strategySignaling

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Area of Science:

  • Microbiology
  • Neonatal Medicine
  • Gastroenterology

Background:

  • Gut microbiota metabolites, known as postbiotics, are increasingly recognized for their health benefits.
  • Necrotizing enterocolitis (NEC) in preterm infants is linked to gut dysbiosis and intestinal immaturity.
  • Current treatments for NEC carry risks, highlighting the need for safer alternatives.

Purpose of the Study:

  • To review the biological effects and mechanisms of postbiotics.
  • To explore the potential of postbiotics as a preventive strategy for NEC in preterm infants.
  • To identify gaps in current research regarding postbiotic efficacy and administration in preterm neonates.

Main Methods:

  • Literature review of studies on gut microbiota, postbiotics, and necrotizing enterocolitis.
  • Analysis of the mechanisms by which postbiotics may confer health benefits.
  • Evaluation of the potential risks and benefits of using postbiotics in preterm infants.

Main Results:

  • Postbiotics are soluble factors from bacterial metabolism with direct or indirect health benefits.
  • Postbiotics may offer a safer alternative to live probiotics for preventing NEC in vulnerable preterm infants.
  • The review highlights the need for clinical trials to establish postbiotic efficacy and optimal usage.

Conclusions:

  • Postbiotics represent a promising avenue for NEC prevention in preterm infants.
  • Further clinical investigation is crucial to validate the efficacy and safety of postbiotics.
  • Optimal dosing, timing, and duration of postbiotic treatment require further research.