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Nuclear ErbB-2: a Novel Therapeutic Target in ErbB-2-Positive Breast Cancer?

Rosalía I Cordo Russo1, María F Chervo2, Santiago Madera2

  • 1Laboratory of Molecular Mechanisms of Carcinogenesis, Instituto de Biología y Medicina Experimental (IBYME), CONICET, Vuelta de Obligado 2490, C1428ADN, Buenos Aires, Argentina. rcordorusso@gmail.com.

Hormones & Cancer
|January 19, 2019
PubMed

Insights

Nuclear ErbB-2 (NErbB-2) plays a key role in breast cancer (BC) growth and metastasis. Targeting NErbB-2 offers a promising new therapeutic strategy for ErbB-2-positive breast cancer.

Area of Science:

  • Oncology
  • Molecular Biology
  • Cancer Research

Background:

  • Membrane ErbB-2 (MErbB-2) overexpression occurs in 15-20% of breast cancers (BC), targeting it improves outcomes.
  • Resistance to MErbB-2 targeted therapies and lack of predictive biomarkers remain significant clinical challenges.
  • Understanding the ErbB-2 signaling pathway is critical for advancing BC treatment.

Purpose of the Study:

  • To review the function of nuclear ErbB-2 (NErbB-2) in breast cancer.
  • To discuss the emerging role of NErbB-2 in BC growth, metastasis, and therapeutic response.
  • To highlight NErbB-2 as a potential novel therapeutic target for ErbB-2-positive BC.

Main Methods:

  • Literature review of studies investigating ErbB-2 signaling.
  • Analysis of research on MErbB-2 canonical pathway and NErbB-2 functions.
  • Synthesis of evidence regarding NErbB-2's role in BC progression and treatment response.

Main Results:

  • MErbB-2 can translocate to the nucleus, acting as a transcriptional regulator (NErbB-2).
  • NErbB-2 is implicated in BC growth and metastasis.
  • Emerging evidence suggests NErbB-2 influences response to anti-MErbB-2 therapies.

Conclusions:

  • The canonical understanding of MErbB-2 action is evolving with the discovery of NErbB-2.
  • NErbB-2 represents a significant factor in BC pathogenesis.
  • Targeting NErbB-2 may offer a novel therapeutic avenue for ErbB-2-positive breast cancer.
Keywords:
Breast cancerErbB-2 signaling pathwayMetastasisNuclear ErbB-2Response to ErbB-2-targeted therapiesTranscriptional coactivator

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