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Stem cells are undifferentiated cells that divide and produce different types of cells. Ordinarily, cells that have differentiated into a specific cell type are post-mitotic—that is, they no longer divide. However, scientists have found a way to reprogram these mature cells so that they “de-differentiate” and return to an unspecialized, proliferative state. These cells are also pluripotent like embryonic stem cells—able to produce all cell types—and are therefore...
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Reference Transcriptome for Deriving Marmoset Induced Pluripotent Stem Cells.

Guang Yang1, Hyenjong Hong1, April Torres1

  • 1Southwest National Primate Research Center, Texas Biomedical Research Institute, San Antonio, TX, USA.

Methods in Molecular Biology (Clifton, N.J.)
|January 19, 2019
PubMed
Summary
This summary is machine-generated.

Generating induced pluripotent stem cell (iPSC) lines from nonhuman primates (NHP) provides a valuable alternative to primary tissue for comparative biology. These validated NHP iPSC lines support translational research by enabling study of cellular diversity and gene regulation.

Keywords:
Marmoset iPSCsNonhuman primate iPSCsPluripotencyRegenerative medicineScorecardiPSC characterization

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Area of Science:

  • Stem cell biology
  • Comparative genomics
  • Translational research

Background:

  • Limited access to nonhuman primate (NHP) primary tissues hinders comparative biology and stem cell translational research.
  • Postmortem tissues offer limited utility for studying cellular diversity and gene regulation.
  • Induced pluripotent stem cell (iPSC) technology offers an alternative to invasive tissue acquisition.

Purpose of the Study:

  • To generate and validate high-quality induced pluripotent stem cell (iPSC) lines from nonhuman primate (NHP) species.
  • To provide these validated NHP iPSC lines to the scientific community to advance research.
  • To establish a resource for studying NHP cellular diversity and gene regulation.

Main Methods:

  • Generation of NHP iPSC lines from skin biopsies using a non-integrative episomal vector system.
  • Validation of pluripotency and differentiation capacity of NHP iPSC lines.
  • Assessment of differentiation into ectoderm, mesoderm, and endoderm using established standards and marker genes.

Main Results:

  • Successful generation of validated NHP iPSC lines.
  • Confirmation of pluripotency in generated NHP iPSC lines.
  • Demonstration of the propensity of NHP iPSC lines to differentiate into all three germ layers.

Conclusions:

  • Validated NHP iPSC lines are a valuable resource for stem cell translational research.
  • These iPSC lines overcome limitations associated with primary tissue access in comparative biology.
  • The generated NHP iPSC lines facilitate the study of species-specific cellular diversity and gene regulation.