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Updated: Jan 30, 2026

Heat-Induced Antigen Retrieval: An Effective Method to Detect and Identify Progenitor Cell Types during Adult Hippocampal Neurogenesis
Published on: August 30, 2013
Method for Stimulation of Hippocampal Neurogenesis by Transient Microneedle Insertion
Shijie Song1,2, Xiaoyung Kong3,4,5, Juan Sanchez-Ramos6,7
1Department of Neurology and Neurosurgery, University of South Florida, Tampa, FL, USA. ssong@health.usf.edu.
Abstract:
Brief stereotaxic insertion and removal of a microneedle into the hippocampus of mice result in stimulation of hippocampal neurogenesis. This approach has been previously applied to a mouse model of Alzheimer's disease (Song et al., Cell Transplant 25:1853-1861, 2016). Further studies of fundamental cellular mechanisms of the brain's response to micro-injury will be useful for investigation of potential neuroprotective and deleterious effects of targeted microlesions and deep brain stimulation in neurodegenerative diseases.
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