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Clinical Response to Induction Chemotherapy Predicts Outcome after Combined-Modality Therapy in Inflammatory Breast
Mauro Loi1,2, Ariane Dunant3, Sahar Ghith1
1a Department of Radiation Oncology , Institut Gustave Roussy , Villejuif , France.
Cancer Investigation
|January 19, 2019
Summary
Achieving a complete clinical response to upfront chemotherapy is a strong predictor of better outcomes for patients with Inflammatory Breast Cancer (IBC). This finding highlights the importance of early treatment response assessment in managing IBC.
Area of Science:
- Oncology
- Clinical Medicine
- Breast Cancer Research
Background:
- Inflammatory Breast Cancer (IBC) is an aggressive form of breast cancer.
- Effective treatment strategies and outcome predictors are crucial for improving patient survival.
- Induction chemotherapy followed by local treatment is a standard approach for non-metastatic IBC.
Purpose of the Study:
- To identify predictors of outcome in patients with non-metastatic Inflammatory Breast Cancer.
- To evaluate the impact of initial chemotherapy response on long-term survival and disease control.
Main Methods:
- Retrospective review of 95 non-metastatic IBC patient files.
- Analysis of outcomes including loco-regional control (LC), disease-free survival (DFS), and overall survival (OS).
- Multivariate analysis to assess the association of clinical response with survival, adjusted for age.
Main Results:
- Complete clinical response (cCR) was achieved in 16% of patients.
- Five-year survival rates: LC 85%, DFS 41%, OS 55%.
- cCR was significantly associated with improved DFS and OS (p=0.02) in multivariate analysis.
Conclusions:
- Clinical response to upfront chemotherapy is a significant predictor of patient outcome in IBC.
- Early assessment of response to neoadjuvant chemotherapy can guide treatment decisions and prognostication.
- Further research into optimizing upfront chemotherapy regimens for IBC patients is warranted.
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