Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Proteases of the elastase type].

L Robert1

  • 1Laboratoire de Biochimie du Tissu Conjonctif (UA CNRS 1174), Faculté de Médecine, Université de Paris XII, Créteil, France.

Pathologie-Biologie
|November 1, 1988
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Presentation.

Pathologie-biologie·2012
Same author

Celebration of the 50th anniversary of the foundation of the French society for connective tissue research. Its short history in the frame of the origin and development of this discipline.

Pathologie-biologie·2012
Same author

Fifty years of structural glycoproteins.

Pathologie-biologie·2012
Same author

[Pathologie Biologie: an evolution].

Pathologie-biologie·2011
Same author

Physiology of skin aging.

Clinics in plastic surgery·2011
Same author

The Maillard reaction--illicite (bio)chemistry in tissues and food.

Pathologie-biologie·2011
Same journal

Pathologie-biologie·2020
Same journal

Antibacterial and antibiofilm activities of Laurus nobilis L. essential oil against Staphylococcus aureus strains associated with oral infections.

Pathologie-biologie·2015
Same journal

[Not Available].

Pathologie-biologie·2015
Same journal

Oxidative damage and histopathological changes in lung of rat chronically exposed to nicotine alone or associated to ethanol.

Pathologie-biologie·2015
Same journal

Biological diagnosis of diabetes mellitus.

Pathologie-biologie·2015
Same journal

Association of CagPAI integrity with severeness of Helicobacter pylori infection in patients with gastritis.

Pathologie-biologie·2015
See all related articles

Cellular elastases, proteases that degrade elastin, contribute to age-related diseases like atherosclerosis and emphysema. Increased elastase activity in fibroblasts and smooth muscle cells impacts cell behavior in these conditions.

Area of Science:

  • Biochemistry
  • Molecular Biology
  • Physiology

Context:

  • Elastin, a resilient fibrous protein, is crucial for vertebrate circulatory and respiratory systems.
  • Degradation of elastic fibers is linked to age-dependent pathologies.

Purpose:

  • To explore the role of cellular elastases in age-related diseases.
  • To discuss the involvement of various cellular proteases in elastin degradation.

Summary:

  • Cellular elastases, including those from leukocytes, platelets, and macrophages, degrade elastin.
  • Fibroblast and smooth muscle cell elastase activity increases with age, influencing cell behavior.
  • These enzymes, though less potent than pancreatic elastase, are implicated in atherosclerosis and emphysema.

Related Experiment Videos

Impact:

  • Understanding cellular elastase function is vital for developing treatments for age-related diseases.
  • Highlights the significance of cellular elastases in physiological and pathological processes.
  • Provides insights into the molecular mechanisms underlying atherosclerosis and emphysema.