Physical exercise among patients with systemic autoimmune myopathies

Area of Science:

• Rheumatology
• Neurology
• Exercise Science

Background:

• Systemic autoimmune myopathies (SAMs) are rare diseases causing progressive skeletal muscle weakness.
• Patients experience functional disabilities, reduced quality of life, and sedentary behavior.
• Exercise is a potential non-pharmacological therapy for SAMs.

Purpose of the Study:

• To systematically review the evidence on exercise training in patients with SAMs.
• To evaluate the potential benefits of physical activity for muscle strength and function.
• To assess the safety of exercise interventions in this population.

Main Methods:

• Systematic literature review.
• Analysis of studies investigating exercise interventions in SAMs patients.
• Evaluation of reported outcomes related to muscle function, strength, and disease activity.

Main Results:

• Evidence suggests exercise training can improve muscle strength and function in SAMs.
• Studies indicate potential benefits for overall clinical aspects of the disease.
• Safety data needs further investigation, but current evidence does not strongly support exercise exacerbating inflammation.

Conclusions:

• Exercise training appears to be a beneficial and potentially safe non-pharmacological approach for SAMs.
• Further high-quality research is needed to establish optimal exercise protocols.
• Physical activity can be considered to improve the health and functional status of patients with SAMs.