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Adipokines in rheumatoid arthritis
Elis Carolina de Souza Fatel1,2, Flávia Troncon Rosa3, Andréa Name Colado Simão4
1Postgraduate Program, Health Sciences Center, State University of Londrina, Londrina, Paraná, Brazil. elis.fatel@uffs.edu.br.
Advances in Rheumatology (London, England)
|January 19, 2019
Summary
This review explores the connection between key adipokines and rheumatoid arthritis (RA). Understanding these factors may offer new insights into managing this chronic autoimmune disease.
Area of Science:
- Rheumatology
- Immunology
- Endocrinology
Background:
- Rheumatoid arthritis (RA) is a chronic, multisystem autoimmune disease affecting millions globally.
- Current RA treatment focuses on symptom relief and functional improvement, but causes remain unknown.
- The role of adipokines in RA pathogenesis is debated, with conflicting research findings.
Purpose of the Study:
- To review the association between key adipokines and rheumatoid arthritis (RA).
- To clarify the role of specific adipokines in RA pathogenesis and progression.
- To highlight the impact of RA as a disabling chronic disease.
Main Methods:
- Literature review of studies investigating adipokines and RA.
- Focus on key adipokines: leptin, resistin, visfatin, and adiponectin.
- Analysis of current evidence on adipokine involvement in RA pathophysiology.
Main Results:
- Conflicting results exist regarding the role of adipokines in RA pathogenesis.
- Some studies suggest adipokines are implicated in the pathophysiology of autoimmune diseases like RA.
- The precise role of adipokines in RA disease progression requires further investigation.
Conclusions:
- Adipokines represent a potential area of interest in understanding RA.
- Further research is needed to elucidate the specific mechanisms linking adipokines to RA.
- Clarifying these associations could inform future RA management strategies.
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