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Autocrine or paracrine models of cytokine production and utilization in B-cell chronic lymphocytic leukaemia
R Foa1, M Giovarelli, M T Fierro
1Dipartimento di Scienze Biomediche e Oncologia Umana, University of Torino, Italy.
Nouvelle Revue Francaise D'Hematologie
|January 1, 1988
Abstract:
The possibility that autocrine or paracrine mechanisms of cytokine production and utilization may take place in patients with B-cell chronic lymphocytic leukaemia (B-CLL) is discussed. In particular, evidence is provided for a likely role of interleukin 2 (IL2) on the neoplastic B-cell compartment. Furthermore, the possibility that tumor necrosis factor (TNF) may also be involved is suggested.