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Related Experiment Video

Updated: Jan 30, 2026

Porcine Model of Infrarenal Abdominal Aortic Aneurysm
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Interleukin-6 Receptor Signaling and Abdominal Aortic Aneurysm Growth Rates.

Ellie Paige1,2, Marc Clément3, Fabien Lareyre3,4,5

  • 1National Centre for Epidemiology and Population Health, Research School of Population Health, The Australian National University, Canberra, Australia (E.P.).

Circulation. Genomic and Precision Medicine
|January 19, 2019
PubMed
Summary

The IL6R-Asp358Ala variant may influence abdominal aortic aneurysm (AAA) size but not growth rate. Blocking IL-6 trans-signaling improved survival in mouse models, suggesting its relevance to AAA progression.

Keywords:
allelesaortic aneurysmgeneticsinflammationinterleukins

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Area of Science:

  • Cardiovascular Genetics
  • Molecular Medicine
  • Atherosclerosis Research

Background:

  • The IL6R-Asp358Ala variant (rs2228145) is linked to abdominal aortic aneurysms (AAAs).
  • The impact of this variant on AAA growth dynamics remains uncharacterized.
  • Investigating IL-6 signaling blockade in AAA pathogenesis is crucial.

Purpose of the Study:

  • To determine the association between the IL6R-Asp358Ala variant and AAA growth.
  • To evaluate the efficacy of IL-6 signaling pathway inhibition in mouse models of AAA.

Main Methods:

  • Analysis of AAA growth in 2863 participants across 9 cohorts using mixed-effects models.
  • Assessment of IL-6 signaling blockade effects on biomarkers, blood pressure, aneurysm diameter, and survival in mouse AAA models.

Main Results:

  • A statistically non-significant trend for reduced AAA growth (-0.06 mm/year) per copy of the minor allele was observed.
  • Selective IL-6 trans-signaling blockade, but not dual pathway blockade, improved survival in mouse AAA models (P<0.05).

Conclusions:

  • IL-6 trans-signaling may play a role in AAA pathogenesis.
  • Further large-scale studies are warranted to validate the role of IL-6 trans-signaling in AAA growth.