Related Experiment Video
Updated: Jan 30, 2026

Ameliorating Osteoarthritis in Mice Using Silver Nanoparticles
Published on: June 2, 2023
Effects of silver nanoparticles functionalized with Cornus mas L. extract on architecture and apoptosis in rat
Razvan Opris1, Vlad Toma2,3,4, Diana Olteanu1
1Department of Physiology, 'Iuliu Hatieganu' University of Medicine & Pharmacy, 1-3 Clinicilor Street, 400006, Cluj-Napoca, Romania.
Aim:
To assess ultrastructural changes, alterations in matrix metalloproteinase activity and apoptosis induced by silver nanoparticles (AgNPs) in the rat testicle.
Materials & Methods:
For 45 days, two groups of animals received different doses of AgNPs (0.8 and 1.5 mg/kg b.w.), and a control group was given the buffer used as vehicle for AgNPs. At 7 and 15 days post-treatment, transmission electron microscopy, TUNEL assay, evaluation of NFkB, pNFkB, p53, Bcl-2 and Nrf2 expressions were performed on the removed testes.
Results:
Transmission electron microscopy revealed severe ultrastructural changes of interstitial tissue and seminiferous epithelium sustained by positive signal for apoptosis. The promatrix metalloproteinase-2 activity and NFkB, Bcl-2 expressions were increased, mainly at 7 days.
Conclusion:
AgNPs induced severe cell lesions identified even a long time after the exposure.
Related Concept Videos
Extraction: Effects of pH
Apoptosis
Polymer Classification: Architecture
Buffer Effectiveness
The buffer capacity is the amount of acid or base that can be added to a given volume...
Framing Effects
Biological Effects of Radiation

