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Reduced parietofrontal effective connectivity during a working-memory task in people with high delusional ideation

Yu Fukuda1, Teresa Katthagen1, Lorenz Deserno1

  • 1From the Charité–Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Department of Psychiatry and Psychotherapy CCM, Berlin, Germany (Fukuda, Katthagen, Kaminski, Heinz, Schlagenhauf); the Department of Child and Adolescent Psychiatry, Psychotherapy and Psychosomatics, University of Leipzig, Leipzig, Germany (Deserno); Department of Neurology, Max-Planck-Institute for Human Cognitive and Brain Sciences, Leipzig, Germany (Deserno, Kaminski, Schlagenhauf); the Columbia University College of Physicians and Surgeons, New York, NY (Shayegan); and the Berlin Institute of Health, Berlin, Germany (Kaminski).

Journal of Psychiatry & Neuroscience : JPN
|January 19, 2019
PubMed
Summary

Individuals with high delusional ideation show altered brain activity and connectivity during working memory tasks, even without behavioral deficits. These findings suggest a continuum of neural changes across psychosis spectrums.

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