Long-term canine duct-occluded segmental pancreatic autografts: endocrine function
P Williamson1, S A Deane, H Ekberg
1Department of Medicine, Westmead Hospital, Australia.
Pancreas
|January 1, 1988
Summary
Duct-occluded segmental pancreatic autografts in dogs show reduced endocrine function but no deterioration up to 5 years. Metabolic control appears adequate to prevent diabetic complications.
Area of Science:
- Endocrinology
- Transplantation Biology
- Metabolic Research
Background:
- Segmental pancreatic autografts are used in transplantation.
- Assessing the long-term endocrine function of these grafts is crucial.
Purpose of the Study:
- To evaluate the endocrine function of duct-obliterated canine segmental pancreatic autografts up to 5 years post-transplant.
- To determine if graft function deteriorates over time.
Main Methods:
- Intravenous and oral glucose tolerance tests were performed.
- Insulin response to glucose and glucagon stimulation was measured.
- Glycosylated hemoglobin levels were assessed.
Main Results:
- Transplanted dogs exhibited significantly lower K-values during intravenous glucose tolerance tests.
- Peak blood glucose levels were higher in autografted dogs after oral glucose stimulation.
- Insulin secretion was reduced in early stages and after glucagon stimulation in autografted dogs.
- No progressive decline in graft function was observed up to 5 years.
- Glycosylated hemoglobin levels did not differ significantly between autografted and normal dogs.
Conclusions:
- Duct-occluded segmental pancreatic autografts possess reduced endocrine capacity.
- Graft function remained stable without deterioration for up to 5 years.
- The achieved metabolic control may be sufficient to avert diabetic complications.
