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FAst Segmentation Through SURface Fairing (FASTSURF): A novel semi-automatic hippocampus segmentation method.

Fabian Bartel1, Hugo Vrenken1, Marcel van Herk2

  • 1Department of Radiology and Nuclear Medicine, VU University Medical Center, Amsterdam, The Netherlands.

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FASTSURF significantly reduces hippocampus segmentation time on MRI scans with high accuracy. This semi-automatic method shows promise for clinical use by accurately measuring atrophy rates with minimal manual effort.

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Area of Science:

  • Neuroimaging
  • Medical Image Analysis
  • Computational Anatomy

Background:

  • Accurate hippocampus segmentation is crucial for diagnosing neurological conditions.
  • Manual segmentation is time-consuming and prone to inter-rater variability.
  • Existing automatic methods may lack the required precision for clinical applications.

Purpose of the Study:

  • To introduce and validate FASTSURF, a semi-automatic method for rapid hippocampus segmentation on MRI.
  • To assess the accuracy and efficiency of FASTSURF compared to manual and other automatic segmentation techniques.
  • To evaluate FASTSURF's capability in quantifying hippocampal atrophy rates.

Main Methods:

  • FASTSURF utilizes a surface fairing technique to reconstruct the hippocampus from sparse user-defined contours.
  • Validation involved comparing FASTSURF segmentations with manual segmentations using Jaccard indices and Percentage Volume Differences (PVD) across multiple datasets.
  • Longitudinal scans were used to compare atrophy rate measurements from FASTSURF, manual, and two automatic methods (FreeSurfer, FSL-FIRST).

Main Results:

  • FASTSURF achieved high mean Jaccard indices (72-83%) and low PVDs (0.02-3.2%) with as few as seven input contours.
  • Performance was slightly reduced in unbiased analyses but remained superior to tested automatic methods with fewer contours.
  • Hippocampal atrophy rates measured by FASTSURF closely correlated with those from manual segmentations.

Conclusions:

  • FASTSURF offers a highly accurate and efficient semi-automatic solution for hippocampus segmentation on MRI.
  • The method requires significantly less manual input compared to full manual segmentation.
  • FASTSURF shows potential for integration into clinical workflows for improved diagnostic efficiency and atrophy assessment.