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Related Experiment Videos

Placebo response in depression: a search for predictors.

W A Brown1, B E Dornseif, J F Wernicke

  • 1Brown University, Providence, RI.

Psychiatry Research
|December 1, 1988
PubMed
Summary

Many patients with depression show improvement with placebo treatment, but predictors are unclear. This study found chronicity might predict placebo response in moderate to severe depression.

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Area of Science:

  • Psychiatry
  • Clinical Psychology
  • Neuroscience

Background:

  • A significant portion of patients with depression (30-40%) exhibit a placebo response.
  • Identifying predictors of placebo response is crucial for understanding treatment mechanisms and improving clinical trial design.

Purpose of the Study:

  • To evaluate predictors of placebo response in patients with moderate to severe depression.
  • To confirm the rate of placebo response in clinical trials for depression.

Main Methods:

  • Analysis of data from two multicenter clinical trials involving patients with moderate to severe depression.
  • Patients received placebo treatment for 3-6 weeks.
  • Placebo response was defined as a greater than 50% improvement in the Hamilton Depression Rating Scale total score.

Main Results:

  • Placebo response rates were 38.4% in Study 1 (n=125) and 30.7% in Study 2 (n=88).
  • Baseline clinical and demographic characteristics did not significantly differ between placebo responders and non-responders.
  • The chronicity of depression emerged as a potential predictor of placebo response.

Conclusions:

  • The study confirms a substantial placebo response rate in patients with moderate to severe depression.
  • Chronicity of depression may be a key factor influencing placebo response.
  • Further research is needed to elucidate the mechanisms behind placebo effects in depression.

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