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Updated: Jan 30, 2026
07:53
Quantification of Antibody-dependent Enhancement of the Zika Virus in Primary Human Cells
Published on: January 18, 2019
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ZIKA virus entry mechanisms in human cells
Almerinda Agrelli1, Ronald Rodrigues de Moura2, Sergio Crovella3
1Laboratory of Immunopathology Keizo Asami (LIKA), Federal University of Pernambuco (UFPE), Av. Prof. Moraes Rego, 1235 - Cidade Universitária, Recife CEP: 50670-901, Brazil.
Summary
Zika virus (ZIKV) enters cells via endocytosis, with its glycoprotein E mediating entry. Incomplete maturation creates diverse particles, influencing ZIKV
Area of Science:
- Virology
- Cell Biology
- Molecular Biology
Background:
- Zika virus (ZIKV) is a mosquito-borne Flavivirus.
- ZIKV infects cells through clathrin-mediated endocytosis and acidic endosome fusion.
- Viral glycoprotein E primarily mediates cell entry, but incomplete maturation also involves protein prM and viral membrane lipids.
Purpose of the Study:
- To review recent advances in understanding ZIKV cell entry.
- To explore fundamental questions regarding ZIKV replication, maturation, and host-cell interactions.
Main Methods:
- Literature review of ZIKV entry mechanisms.
- Analysis of viral particle heterogeneity and its impact on cell tropism.
Main Results:
- Incomplete proteolytic maturation leads to heterogeneous ZIKV particles.
- Particle surface variations offer diverse receptor interaction sites.
- This heterogeneity contributes to ZIKV's broad cell susceptibility and tissue tropism.
Conclusions:
- Understanding ZIKV entry mechanisms is crucial for controlling viral spread.
- Further research into ZIKV replication, maturation, and host interactions is warranted.
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