Related Experiment Video
Updated: Jan 30, 2026

Author Spotlight: Sieving Fruit Pulp to Detect Immature Tephritid Fruit Flies in the Field
Published on: July 28, 2023
Influence of Ellagitannins Extracted by Pomegranate Fruit on Disulfide Isomerase PDIA3 Activity
Fabio Altieri1,2, Francesco Cairone3, Flavia Giamogante4
1Dipartimento di Scienze Biochimiche "A. Rossi Fanelli", Università degli Studi di Roma "La Sapienza", Piazzale A. Moro, 5-00185 Rome, Italy. fabio.altieri@uniroma1.it.
Abstract:
Pomegranate fruit is a functional food of high interest for human health due to its wide range of phytochemicals with antioxidant properties are implicated in the prevention of inflammation and cancer. Ellagitannins, such as punicalagin and ellagic acid, play a role as anti-atherogenic and neuroprotective molecules in the complex fighting against the degenerative diseases. The aim of this work was to evaluate the composition in punicalagins and ellagic acid of differently obtained extracts from whole fruit, peels and juices, prepared by squeezing or by centrifugation, of pomegranate belonging to different cultivars. Moreover, a wider phenolic fingerprint was also determined. The bioactivity of the extracts was tested on the redox activity of PDIA3 disulfide isomerase, an enzyme involved in the regulation of several cellular functions and associated with different diseases such as cancer, prion disorders, Alzheimer's and Parkinson's diseases. The results demonstrate that the different ratios between punicalagin and ellagic acid modulate the enzyme activity and other ellagitannins could interfere with this activity.
Related Concept Videos
Fruit Development, Structure, and Function
The Influence of Affect on Cognition
The Influence of Cognition on Affect
Bioavailability: Influencing Factors
Biological Influences on Intelligence
Environmental Influences on Intelligence

