Related Experiment Video
Updated: Jan 30, 2026

High-throughput Analysis of Locomotor Behavior in the Drosophila Island Assay
Published on: November 5, 2017
Comparative analysis reveals the Genomic Islands in Pasteurella multocida population genetics: on Symbiosis and
Dekang Zhu1,2, Jiao He1,2, Zhishuang Yang1,3,2
1Research Center of Avian Diseases, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu, Sichuan, China.
Background:
Pasteurella multocida (P. multocida) is a widespread opportunistic pathogen that infects human and various animals. Genomic Islands (GIs) are one of the most important mobile components that quickly help bacteria acquire large fragments of foreign genes. However, the effects of GIs on P. multocida are unknown in the evolution of bacterial populations.
Results:
Ten avian-sourced P. multocida obtained through high-throughput sequencing together with 104 publicly available P. multocida genomes were used to analyse their population genetics, thus constructed a pan-genome containing 3948 protein-coding genes. Through the pan-genome, the open evolutionary pattern of P. multocida was revealed, and the functional components of 944 core genes, 2439 accessory genes and 565 unique genes were analysed. In addition, a total of 280 GIs were predicted in all strains. Combined with the pan-genome of P. multocida, the GIs accounted for 5.8% of the core genes in the pan-genome, mainly related to functional metabolic activities; the accessory genes accounted for 42.3%, mainly for the enrichment of adaptive genes; and the unique genes accounted for 35.4%, containing some defence mechanism-related genes.
Conclusions:
The effects of GIs on the population genetics of P. multocida evolution and adaptation to the environment are reflected by the proportion and function of the pan-genome acquired from GIs, and the large quantities of GI data will aid in additional population genetics studies.
More Related Videos
Related Concept Videos
What is Population Genetics?
Symbiosis
Comparing Mitochondrial, Chloroplast, and Prokaryotic Genomes
Conservation of Small Populations
Comparing the Survival Analysis of Two or More Groups
Genomics

