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Updated: Jan 30, 2026

Assessment of Waste-Derived Biochars on the Health and Biological Activity of Soil
Published on: October 10, 2025
Chain conformation and biological activities of hyperbranched fucoidan derived from brown algae and its desulfated
Xueqin Wei1, Liqin Cai1, Hailing Liu2
1College of Chemistry and Molecular Sciences, Wuhan University, Wuhan, 430072, China.
Abstract:
A fucoidan derived from marine brown algae has great potential in biomedical filed. Herein, the fucoidan was successfully isolated and purified by using chitosan microspheres, resulting in the sulfate fucoidan (CF) with degree of sulfation (DS) of 0.94. CF was identified to be highly branched, consisting of fucose (77.4%) and galactose (13.9%), etc., supported by the results of GCMS and light scattering with the structure-sensitive parameter of 0.98 in 0.15 M aqueous NaNO3. The individual CF and its desulfated derivative chains adopted sphere-like conformation in water, observed by atomic force microscopy. CF exhibited higher antiangiogenesis than the desulfated one and strong antileukemia activities through inhibiting cell proliferation and inducing cell apoptosis via cell cycle arrest at G1 phase in vitro. This work provided important information that ester sulfate groups of polysaccharide played an important role in the enhancing of bioactivities of fucoidan, and put forward to a potential drug to treat acute myelocytic leukemia (AML) and tumors.
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