Gaucher's disease and pregnancy.

Area of Science:

• Obstetrics and Gynecology
• Hematology
• Genetic Metabolic Disorders

Background:

• Gaucher's disease is a rare genetic disorder affecting the reticuloendothelial system.
• Pregnancy in Gaucher's disease presents unique management challenges.
• Previous literature suggested a low risk of hemorrhagic complications.

Observation:

• This report details two cases of Gaucher's disease during pregnancy.
• One patient experienced severe puerperal hemorrhage.
• Hemorrhage was linked to thrombocytopenia caused by Gaucher cell infiltration.

Findings:

• The study challenges the established view on the absence of hemorrhagic complications in pregnancy with Gaucher's disease.
• Severe bleeding can occur, even late in the puerperium.
• Thrombocytopenia is a significant risk factor, resulting from Gaucher cell infiltration.

Implications:

• Clinical vigilance for hemorrhagic complications in pregnant Gaucher's disease patients is crucial.
• Management strategies may need re-evaluation to address potential late-onset bleeding.
• Further research is warranted to understand and mitigate these risks.