Related Experiment Video
Updated: Jan 30, 2026
06:39
Author Spotlight: Exploring Photodynamic Therapy with Curcumin in a Murine Model for Oral Candidiasis
Published on: October 27, 2023
1.5K
Rationalizing antimicrobial therapy in the ICU: a narrative review
Jean-François Timsit1,2, Matteo Bassetti3, Olaf Cremer4
1Medical and Infectious Diseases ICU, APHP, Bichat-Claude Bernard Hospital, 46 Rue Henri-Huchard, 75877, Paris Cedex 18, France. jean-francois.timsit@aphp.fr.
Intensive Care Medicine
|January 20, 2019
Summary
Optimizing antibiotic use in the ICU is crucial to combat multidrug-resistant bacteria (MDRB). Implementing antibiotic stewardship programs (ASP) can improve patient outcomes and reduce resistance.
Area of Science:
- Critical Care Medicine
- Infectious Diseases
- Pharmacology
Background:
- Intensive care units (ICUs) face significant antibiotic overuse, driving multidrug-resistant bacteria (MDRB) spread.
- Many ICU patients receive empirical antibiotics without confirmed infections, and treatment durations are often not shortened, even with sepsis.
Purpose of the Study:
- To review current evidence, new strategies, and ongoing debates regarding optimal antibiotic therapy in the ICU.
- To advocate for antibiotic stewardship programs (ASP) to improve patient care and mitigate resistance.
Main Methods:
- This is a narrative review synthesizing published data and expert opinion.
- Focuses on identifying at-risk patients, diagnostic accuracy, and individualized treatment regimens.
Main Results:
- Evidence supports enhanced MDRB risk identification and diagnostic tools for bacterial sepsis.
- Individualized empirical regimens, appropriate dosing, source control, and de-escalation are key.
- Systematic reassessment of therapy can minimize harm to commensal flora.
Conclusions:
- Actionable ASP in ICUs can lead to better patient outcomes.
- ASP implementation is vital for reducing antibiotic selection pressure and controlling MDRB dissemination.
Keywords:
Antibiotic stewardshipAntimicrobial resistanceCarbapenemCritical illnessEmpirical therapyOutcomeSepsisMore Related Videos
14:32Using Visual and Narrative Methods to Achieve Fair Process in Clinical Care
Published on: February 16, 2011
24.9K
09:29In Vivo Investigation of Antimicrobial Blue Light Therapy for Multidrug-resistant Acinetobacter baumannii Burn Infections Using Bioluminescence Imaging
Published on: April 28, 2017
9.9K
Related Concept Videos
01:24Rational Emotive Behavior Therapy
434
Cognitive-behavioral therapies (CBTs) are grounded in the belief that our thoughts profoundly influence our emotions and actions. Advocates of CBT emphasize three core assumptions: first, that cognitions are identifiable and measurable; second, that they are central to psychological functioning; and third, that irrational or maladaptive beliefs can be replaced with rational and adaptive ones. This transformative approach to therapy has paved the way for specific models such as Albert...
434
01:16Treating Helicobacter pylori in Peptic Ulcers: Antimicrobial Therapy
1.3K
Helicobacter pylori, a resilient gram-negative bacterium, can thrive in the stomach's harsh, acidic environment. Infection with H. pylori leads to a cascade of events within the stomach lining. One of the critical disruptions caused by this bacterium is the interference with somatostatin production, a hormone responsible for regulating acid secretion. This interference tips the balance, escalating acid secretion and diminishing bicarbonate levels. This imbalance compromises the defensive...
1.3K
01:28Rational Expressions
391
Rational expressions are algebraic fractions in which both the numerator and the denominator are polynomials. These expressions follow the arithmetic rules of numerical fractions but require extra care due to the presence of variables. A fundamental part of working with rational expressions is identifying values that make the expression undefined, typically those that result in division by zero or undefined radicals.Determining the DomainThe domain of a rational expression includes all real...
391
01:29Rationalizing Substitutions
59
Integrals involving non-rational functions are often difficult to evaluate using standard techniques, especially when radicals appear in the integrand. Rationalizing substitution provides a systematic method for simplifying such integrals by converting them into rational forms that are easier to handle.Consider a rod whose linear mass density depends on a constant linear density, a characteristic length, and the distance from the left end of the rod. Determining the total mass requires...
59
01:10Review and Preview
8.4K
In statistics, several tools are used to interpret the data. Measures of central tendency represent the characteristics of the data, such as mean, median, and mode. Additionally, measures of variance like standard deviation and range are used to find the spread of data from the mean. Relative standing measures the distance between data locations. Commonly used measures of relative standings are percentile, z score, and quartiles.
Percentiles are a type of fractile that partition data into...
Percentiles are a type of fractile that partition data into...
8.4K
01:13Review and Preview
11.2K
Data are individual items of information obtained from a population or sample. Data may be classified as qualitative (categorical), quantitative continuous, or quantitative discrete. Because it is not practical to measure the entire population in a study, researchers use samples to represent the population. A random sample is a representative group from the population chosen by using a method that gives each individual in the population an equal chance of being included in the sample. Random...
11.2K