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Updated: Jan 30, 2026

Trabecular Meshwork Response to Pressure Elevation in the Living Human Eye
Published on: June 20, 2015
Trabecular meshwork cells are a valuable resource for cellular therapy of glaucoma
Hong Sun1, Qin Zhu2, Ping Guo3
1Department of Ophthalmology, the First Affiliated Hospital of Nanjing Medical University, Nanjing, China.
Abstract:
Trabecular meshwork (TM) contains a subset of adult stem cells or progenitors that can be differentiated into corneal endothelial cells, adipocytes and chondrocytes, but not osteocytes or keratocytes. Accordingly, these progenitors can be utilized as a cell-based therapy to prevent blindness caused by glaucoma, corneal endothelial dysfunction and other diseases in general. In this review, we review in vitro expansion techniques for TM progenitors, discuss their phenotypic properties, and highlight their potential clinical applications in various ophthalmic diseases.
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