Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Interference and Diffraction02:18

Interference and Diffraction

52.4K
Interference is a characteristic phenomenon exhibited by waves. When two electromagnetic waves interact with their peaks and troughs coinciding, a resulting wave with enhanced amplitude is produced. This is known as constructive interference. In this case, the two waves interacting are in phase with each other.
52.4K
RNA Interference01:23

RNA Interference

28.0K
RNA interference (RNAi) is a process in which a small non-coding RNA molecule blocks the post-transcriptional expression of a gene by binding to its messenger RNA (mRNA) and preventing the protein from being translated.
This process occurs naturally in cells, often through the activity of genomically-encoded microRNAs. Researchers can take advantage of this mechanism by introducing synthetic RNAs to deactivate specific genes for research or therapeutic purposes. For example, RNAi could be used...
28.0K
Nature and Nurture01:10

Nature and Nurture

22.3K
Many human characteristics, like height, are shaped by both nature—in other words, by our genes—and by nurture, or our environment. For example, chronic stress during childhood inhibits the production of growth hormones and consequently reduces bone growth and height. Scientists estimate that 70-90% of variation in height is due to genetic differences among individuals, and 10-30% of variation in height is due to differences in the environments that individuals experience,...
22.3K
What is Natural Selection?01:32

What is Natural Selection?

128.9K
Natural selection is an evolutionary process in which individuals with survival-promoting traits reproduce at higher rates. These favorable traits become more common within a population or species. Naturally selected traits initially arise via random genetic mutations. In order for selection to occur, there must be variation within a population, the trait controlling the variation must be heritable, and there must be an evolutionary advantage for variation in the trait.
128.9K
Interference and Decay01:16

Interference and Decay

464
Forgetting is a complex cognitive phenomenon influenced by several factors, among which interference and decay are particularly prominent. These processes explain why individuals often struggle to retrieve specific information from memory, leading to lapses in recall that can be observed in everyday situations.
Interference occurs when competing memories hinder the retrieval of particular information. It can be classified into two types: proactive and retroactive interference. Proactive...
464
Sound Waves: Interference00:53

Sound Waves: Interference

4.7K
Sound waves can be modeled either as longitudinal waves, wherein the molecules of the medium oscillate around an equilibrium position, or as pressure waves. When two identical waves from the same source superimpose on each other, the combination of two crests or two troughs results in amplitude reinforcement known as constructive interference. If two identical waves, that are initially in phase, become out of phase because of different path lengths, the combination of crests with troughs...
4.7K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Composition of Immune Cells in Sporadic Vestibular Schwannomas with Different Tumor Volumes.

Cancers·2026
Same author

Gne-Depletion in C2C12 Myoblasts Leads to Alterations in Glycosylation and Myopathogene Expression.

Cells·2026
Same author

Hybrid neurofibroma/schwannoma in schwannomatosis-a diagnostically challenging benign peripheral nerve sheath tumour.

Familial cancer·2025
Same author

Primary culture of inner ear schwannoma.

Journal of neuroscience methods·2025
Same author

Enhancing drug release from PEG-PLGA implants: The role of Hydrophilic Dexamethasone Phosphate in modulating release kinetics and degradation behavior.

European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences·2025
Same author

Revised Classification of Inner Ear Schwannomas.

Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology·2024

Related Experiment Video

Updated: Jan 30, 2026

A Novel Feeder-free System for Mass Production of Murine Natural Killer Cells In Vitro
10:36

A Novel Feeder-free System for Mass Production of Murine Natural Killer Cells In Vitro

Published on: January 9, 2018

7.6K

Glycation interferes with natural killer cell function.

Philip Rosenstock1, Veronika Bezold1, Kaya Bork1

  • 1Institute for Physiological Chemistry, Martin-Luther-University Halle-Wittenberg, Hollystr. 1, D-06114, Halle/Saale, Germany.

Mechanisms of Ageing and Development
|January 20, 2019
PubMed
Summary

Advanced glycation end products (AGEs) impair natural killer (NK) cell function. Methylglyoxal (MGO) negatively impacts NK cell cytotoxicity more than glyoxal (GO), reducing tumor cell lysis.

Keywords:
AGEsAgingCarbonyl stressGlycationImmune systemNK cells

More Related Videos

Analysis of Human Natural Killer Cell Metabolism
09:03

Analysis of Human Natural Killer Cell Metabolism

Published on: June 22, 2020

7.4K
Teasing Out the Interplay Between Natural Killer Cells and Nociceptor Neurons
09:40

Teasing Out the Interplay Between Natural Killer Cells and Nociceptor Neurons

Published on: June 30, 2022

2.7K

Related Experiment Videos

Last Updated: Jan 30, 2026

A Novel Feeder-free System for Mass Production of Murine Natural Killer Cells In Vitro
10:36

A Novel Feeder-free System for Mass Production of Murine Natural Killer Cells In Vitro

Published on: January 9, 2018

7.6K
Analysis of Human Natural Killer Cell Metabolism
09:03

Analysis of Human Natural Killer Cell Metabolism

Published on: June 22, 2020

7.4K
Teasing Out the Interplay Between Natural Killer Cells and Nociceptor Neurons
09:40

Teasing Out the Interplay Between Natural Killer Cells and Nociceptor Neurons

Published on: June 30, 2022

2.7K

Area of Science:

  • Immunology
  • Molecular Biology
  • Aging Research

Background:

  • Molecular aging is characterized by the accumulation of advanced glycation end products (AGEs).
  • Reactive carbonyls like glyoxal (GO) and methylglyoxal (MGO) are key contributors to AGE formation.
  • Elevated dicarbonyl levels are observed in aging and age-related diseases, impacting immune function.

Purpose of the Study:

  • To investigate the impact of GO- and MGO-induced glycation on natural killer (NK) cell function.
  • To assess the effects of glycation on NK cell cytotoxicity and cytokine production.
  • To determine if glycation of target cells affects NK cell-mediated lysis.

Main Methods:

  • Utilized the human NK cell line NK-92 for experimental analysis.
  • Exposed NK cells and K562 tumor cells to glyoxal (GO) and methylglyoxal (MGO).
  • Assessed NK cell protein glycation levels and functional parameters, including cytotoxicity.

Main Results:

  • Both GO and MGO induced glycation of proteins in NK cells.
  • Methylglyoxal (MGO) significantly impaired NK cell function and cytotoxicity compared to glyoxal (GO).
  • Glycation of target tumor cells (K562) also reduced their susceptibility to NK cell lysis.

Conclusions:

  • Glycation negatively affects NK cell function and cytotoxic potential.
  • MGO poses a greater threat to NK cell-mediated anti-tumor immunity than GO.
  • These findings highlight glycation as a detrimental factor in immune surveillance against cancer.