Patterns of functional connectivity in an aging population: The Rotterdam Study
Hazel I Zonneveld1, Raimon Hr Pruim2, Daniel Bos3
1Department of Radiology and Nuclear Medicine, Erasmus MC University Medical Centre Rotterdam, the Netherlands; Department of Epidemiology, Erasmus MC University Medical Centre Rotterdam, the Netherlands.
Neuroimage
|January 20, 2019
Summary
Older age is associated with altered functional brain connectivity. Resting-state functional connectivity decreases in some networks but increases in others, suggesting brain reorganization during aging.
Area of Science:
- Neuroscience
- Aging Research
- Brain Imaging
Background:
- Structural brain changes are late markers of neurodegeneration.
- Functional connectivity is a potential early marker for neurodegeneration.
- Normal aging also affects brain structure and function.
Purpose of the Study:
- Investigate the relationship between age and resting-state functional connectivity.
- Examine functional connectivity changes in non-demented individuals.
- Understand how aging impacts brain networks.
Main Methods:
- Analyzed resting-state functional connectivity in 2878 non-demented individuals (50-95 years).
- Utilized data-driven methods to identify nine resting-state networks.
- Correlated age with functional connectivity within and between networks.
Main Results:
- Decreased functional connectivity with age in anterior default mode, ventral attention, and sensorimotor networks.
- Increased functional connectivity with age in the visual network.
- Observed both increases and decreases in connectivity between resting-state networks.
Conclusions:
- The aging brain exhibits a reorganization process.
- Functional connectivity patterns vary with age across different brain networks.
- Findings support exploring functional connectivity as a preclinical marker for neurodegenerative diseases.
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