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Techniques to Induce and Quantify Cellular Senescence
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Cellular senescence in bone.

Joshua N Farr1, Sundeep Khosla1

  • 1Division of Endocrinology and Metabolism and Kogod Center on Aging, Mayo Clinic, Rochester, MN, USA.

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|January 20, 2019
PubMed
Summary
This summary is machine-generated.

Cellular senescence, a key aging process, drives age-related diseases but targeting it with senotherapeutics can extend healthspan. Eliminating senescent cells shows promise for treating conditions like osteoporosis.

Keywords:
AgingBoneDisease preventionOsteocyteOsteoporosis

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Area of Science:

  • Cellular and Molecular Biology
  • Gerontology
  • Immunology

Background:

  • Cellular senescence is a stress-induced state of irreversible cell cycle arrest with significant cellular changes.
  • Senescent cells and their secreted factors (SASP) have dual roles: beneficial in acute repair and detrimental in chronic aging diseases.
  • Accumulation of senescent cells contributes to age-related pathologies and reduced healthspan.

Purpose of the Study:

  • To investigate the role of cellular senescence in age-related bone loss.
  • To evaluate the efficacy of senotherapeutics (senolytics and senomorphics) in preclinical models of aging and bone loss.

Main Methods:

  • Studies in mice and humans to identify senescent cells in the bone microenvironment.
  • Genetic and pharmacological interventions to reduce senescent cell burden.
  • Assessment of bone loss and comparison with anti-resorptive therapies.

Main Results:

  • Aging leads to senescence in bone microenvironment cells, producing a heterogeneous SASP.
  • Reducing senescent cell burden in aged mice alleviated age-related bone loss.
  • Senotherapeutic interventions demonstrated advantages over traditional anti-resorptive therapies.

Conclusions:

  • Targeting cellular senescence is a promising anti-aging strategy to improve healthspan.
  • Senotherapeutics offer a novel approach to combat age-related diseases, including osteoporosis.
  • These findings support the translation of senotherapeutics to human clinical trials for aging-related conditions.