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Cut-off values for positive bronchodilator response in healthy Thai preschool children using forced oscillation

Kanokporn Udomittipong1, Jurairut Triwatanawong1, Akarin Nimmannit2

  • 1Division of Pulmonology,Department of Pediatrics, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.

Asian Pacific Journal of Allergy and Immunology
|January 21, 2019
PubMed

Insights

This study establishes crucial cut-off values for bronchodilator response using the forced oscillation technique (FOT) in healthy Thai children. These findings aid in diagnosing respiratory conditions like asthma in young patients.

Area of Science:

  • Pediatric Pulmonology
  • Respiratory Physiology

Background:

  • The forced oscillation technique (FOT) is suitable for pediatric respiratory assessments due to minimal cooperation requirements.
  • Bronchodilator testing is vital for diagnosing wheezy and asthmatic conditions.
  • Establishing normative bronchodilator response cut-offs in healthy Thai children using FOT is currently lacking.

Purpose of the Study:

  • To determine the cut-off values for a positive bronchodilator response in healthy Thai preschool children.
  • Utilizing the pseudorandom forced oscillation technique (FOT) for accurate measurement.

Main Methods:

  • Respiratory function was measured using FOT in healthy Thai children aged 3-6 years, before and after salbutamol administration.
  • Respiratory resistance (Rrs) and reactance (Xrs) were recorded at 6, 8, and 10 Hz.
  • Cut-off values were defined as mean ± 1.96 SD of absolute and percent changes; correlations with baseline data were analyzed.

Main Results:

  • FOT measurements were successfully completed in 111 out of 150 children.
  • No significant correlations were found between bronchodilator response and gender, age, height, or arm span.
  • Established cut-off values for percent change in bronchodilator response include Rrs6: -23%, Rrs8: -20%, Rrs10: -20%, Xrs6: 36%, Xrs8: 60%, and Xrs10: 43%.

Conclusions:

  • The determined cut-off values are valuable for assessing bronchodilator responsiveness in young children with wheeze and asthma.
  • This research provides essential reference data for pediatric respiratory diagnostics in Thailand.
Abstract

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