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Creation of a Porcine Kyphotic Model
Richard H Gross1, Yongren Wu1, Daniel J Bonthius2
1Department of Bioengineering, Clemson University, Clemson, SC 29634, USA; Department of Orthopaedics, Medical University of South Carolina, Charleston, SC 29425, USA.
Spine Deformity
|January 21, 2019
Summary
Researchers created a new animal model for thoracic hyperkyphosis in immature pigs. This model will help validate spinal instrumentation and therapies for early-onset scoliosis (EOS).
Area of Science:
- Orthopedics and Spinal Surgery
- Animal Models for Disease Research
- Pediatric Spinal Deformities
Background:
- Scoliosis animal models exist, but thoracic hyperkyphosis models in immature animals are lacking.
- Early-onset scoliosis (EOS) treatment requires reliable models for validating interventions.
- This study aimed to develop a porcine model mimicking pediatric hyperkyphosis.
Purpose of the Study:
- To create a reproducible thoracic hyperkyphotic deformity in an immature porcine spine.
- To establish a model for future research validating spinal instrumentation and therapies for hyperkyphosis.
- To provide a preclinical tool for studying early-onset scoliosis (EOS).
Main Methods:
- Surgical creation of thoracic hyperkyphosis in 6 immature Yorkshire pigs (10 kg).
- Procedure involved thoracotomy, screw fixation, partial vertebrectomy, ligament transection, and wire loop placement.
- Weekly X-rays monitored kyphosis progression; CT and histology confirmed deformity post-necropsy.
Main Results:
- Average T9-T11 kyphosis increased from 6.1° preoperatively to 50.3° at necropsy (p < .0001).
- Significant kyphosis progression was observed over 5-6 weeks as pigs grew.
- The created model demonstrated a relatively rigid thoracic hyperkyphotic deformity.
Conclusions:
- A novel animal model for thoracic hyperkyphosis in immature pigs has been successfully developed.
- This model provides a foundation for future studies on spinal instrumentation for early-onset kyphosis.
- Enables validation of novel therapeutic strategies for pediatric spinal deformities.
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