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Activation of Apoptosis by Cytoplasmic Microinjection of Cytochrome c
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Activation of Apoptosis by Cytoplasmic Microinjection of Cytochrome c

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Bisdemethoxycurcumin protects against renal fibrosis via activation of fibroblast apoptosis

Fuquan Jin1, Ying Jin1, Jiangxia Du1

  • 1Institute of Pharmacology & Toxicology, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China.

European Journal of Pharmacology
|January 21, 2019
PubMed

Insights

Bisdemethoxycurcumin effectively treats kidney fibrosis by inducing fibroblast apoptosis. This natural compound shows promise for developing new therapies for chronic kidney disease (CKD) patients.

Area of Science:

  • Natural Product Chemistry
  • Renal Pathophysiology
  • Pharmacology

Background:

  • Renal fibrosis is a critical determinant of progression in chronic kidney diseases (CKD) towards end-stage renal failure.
  • Current therapeutic options for renal fibrosis are limited, highlighting the need for novel treatment strategies.
  • Plant-derived natural products represent a promising source for antifibrotic agents.

Purpose of the Study:

  • To screen natural products for renal fibrosis-alleviating effects.
  • To evaluate the therapeutic potential of bisdemethoxycurcumin in a mouse model of renal fibrosis.
  • To elucidate the mechanism underlying the antifibrotic action of bisdemethoxycurcumin.

Main Methods:

  • Screening of natural products for antifibrotic activity.
  • Establishment of a mouse model of unilateral ureteral obstruction (UUO) to induce renal fibrosis.
  • In vitro and in vivo experiments to assess the efficacy of bisdemethoxycurcumin.
  • Investigation of the molecular mechanism, including fibroblast apoptosis induction.

Main Results:

  • Bisdemethoxycurcumin demonstrated significant attenuation of renal fibrosis in the UUO mouse model.
  • The antifibrotic effect of bisdemethoxycurcumin was confirmed both in vitro and in vivo.
  • Bisdemethoxycurcumin specifically induced fibroblast apoptosis at a concentration of 20 μM, mediating its therapeutic action.

Conclusions:

  • Bisdemethoxycurcumin is a potent natural compound with significant therapeutic potential for renal fibrosis.
  • The mechanism involves the targeted induction of fibroblast apoptosis.
  • This finding offers a novel therapeutic strategy for managing chronic kidney diseases and preventing renal failure.
Keywords:
ApoptosisBisdemethoxycurcuminFibroblastsNatural compoundsRenal fibrosis

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