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Updated: Jan 30, 2026

Detection and Isolation of Viable Mouse IL-17-Secreting T Cells
12:38

Detection and Isolation of Viable Mouse IL-17-Secreting T Cells

Published on: December 18, 2008

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miR-17∼92 in lymphocyte development and lymphomagenesis

Verena Labi1, Katia Schoeler1, Doron Melamed2

  • 1Division of Developmental Immunology, Biocenter, Innsbruck Medical University, Innsbruck, 6020, Austria.

Cancer Letters
|January 21, 2019
PubMed

Insights

MicroRNAs (miRNAs) regulate protein levels by targeting messenger RNAs. The miR-17∼92 cluster is crucial for lymphocyte development and immune responses, but its overexpression can drive lymphoid tumors.

Area of Science:

  • Molecular Biology
  • Immunology
  • Cancer Biology

Background:

  • MicroRNAs (miRNAs) are small non-coding RNAs that regulate gene expression post-transcriptionally.
  • The miR-17∼92 cluster is a key miRNA polycistron with significant roles in cellular processes.

Purpose of the Study:

  • To review the multifaceted roles of the miR-17∼92 cluster miRNAs in lymphocyte development and homeostasis.
  • To explore the involvement of miR-17∼92 miRNAs in immune responses and their implications in lymphoid malignancies.

Main Methods:

  • This review synthesizes existing literature on miRNA function, gene regulation, and immunological pathways.
  • Analysis of studies investigating the miR-17∼92 cluster in mouse models and human diseases.

Main Results:

  • The miR-17∼92 cluster miRNAs are essential for proper lymphocyte development and adaptive immunity.
  • Dysregulation of miR-17∼92 cluster miRNAs, particularly overexpression, is linked to oncogenesis in lymphoid tissues.
  • These miRNAs fine-tune Phosphoinositide 3-kinase (PI3K) signaling, critical for lymphocyte homeostasis.

Conclusions:

  • The miR-17∼92 cluster plays a dual role in immunity, promoting normal function but also contributing to cancer when overexpressed.
  • Understanding miR-17∼92 miRNA regulation is vital for addressing immune disorders and lymphoid cancers.
Keywords:
B cellsLymphomaT cellsmiR-17∼92microRNA

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