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The Impact of Immunodeficiency on NK Cell Maturation and Function
Alexander Vargas-Hernández1,2, Lisa R Forbes3,4
1Department of Pediatrics, Immunology Allergy and Rheumatology, Baylor College of Medicine, Houston, TX, USA.
Current Allergy and Asthma Reports
|January 21, 2019
Summary
Natural killer (NK) cell deficiencies impact host defense against viruses and cancer. This review details NK cell biology, focusing on defects in combined immune deficiencies for better understanding of NK cell development and function.
Area of Science:
- Immunology
- Cell Biology
Background:
- Natural killer (NK) cells are crucial innate lymphoid cells (ILCs) for host defense against viral infections and malignancy.
- NK cell deficiencies (NKD) encompass conditions affecting NK cell development or function, impacting congenital immunity.
Purpose of the Study:
- To review NK cell biology, focusing on defects observed in combined immune deficiencies.
- To enhance understanding of NK cell development and function through analysis of recent findings.
Main Methods:
- Review of recent literature on natural killer cell defects.
- Analysis of combined immune deficiencies with significant NK cell impairment.
Main Results:
- NK cell deficiencies are categorized into classical (absent/low NK cells) and functional (impaired NK cell function).
- Combined immune deficiencies with NK cell impact offer insights into NK cell biology.
- Defects in NK cell development and function are highlighted in various immunodeficiency contexts.
Conclusions:
- Understanding NK cell defects in combined immune deficiencies is key to advancing knowledge of NK cell biology.
- This review provides insights into the critical roles of NK cells in immunity and disease.
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