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Evidence that TNF-β induces proliferation in colorectal cancer cells and resveratrol can down-modulate it

Constanze Buhrmann1, Mina Yazdi1, Bastian Popper2

  • 11 Musculoskeletal Research Group and Tumor Biology, Chair of Vegetative Anatomy, Faculty of Medicine, Ludwig-Maximilian-University Munich, Munich 80336, Germany.

Experimental Biology and Medicine (Maywood, N.J.)
|January 22, 2019
PubMed
Abstract

Insights

Resveratrol effectively inhibits tumor growth by blocking the TNF-β signaling pathway. This natural compound targets key cancer-promoting factors like NF-κB, offering therapeutic potential against various cancers.

Area of Science:

  • Oncology
  • Molecular Biology
  • Natural Products Chemistry

Background:

  • Tumor necrosis factor-beta (TNF-β) promotes cancer proliferation, invasion, and survival.
  • The precise mechanism of resveratrol's anti-tumor effects, particularly against TNF-β, remains unclear.

Purpose of the Study:

  • To investigate resveratrol's impact on TNF-β-stimulated signaling in HCT116 cancer cells.
  • To compare resveratrol's effects on TNF-β-induced pathways with those of TNF-α.

Main Methods:

  • Utilized HCT116 cells to study TNF-β and TNF-α signaling pathways.
  • Assessed the activation of nuclear factor-kappa B (NF-κB) and its downstream targets.
  • Measured caspase-3 cleavage to evaluate apoptosis induction.

Main Results:

  • TNF-β, similar to TNF-α, activates NF-κB and related genes, promoting cancer progression.
  • Resveratrol effectively blocks TNF-β/TNF-β-receptor-induced NF-κB activation.
  • Resveratrol inhibits NF-κB-modulated gene products and promotes caspase-3 cleavage, indicating apoptosis.

Conclusions:

  • Resveratrol demonstrates significant anti-tumor activity by targeting multiple cellular signaling pathways.
  • Blocking the TNF-β/NF-κB axis is a key mechanism for resveratrol's therapeutic effects.
  • Resveratrol holds promise as a multi-targeting agent for cancer therapy.
Keywords:
NF-κBResveratrolTNF-βcolorectal cancerproliferation

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