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Immunotherapy in advanced gastric cancer, is it the future?

C Coutzac1, S Pernot1, N Chaput2

  • 1Department of Gastroenterology and Digestive Oncology, European Georges Pompidou Hospital, Assistance Publique-Hôpitaux de Paris, Paris, France; Paris Descartes University, Sorbonne Paris Cité, Paris, France.

Critical Reviews in Oncology/Hematology
|January 22, 2019
PubMed

Insights

Immunotherapy targeting the programmed cell death-1 (PD-1) and programmed cell death-1 ligand (PD-L1) axis shows promise for advanced gastric cancer. Identifying predictive biomarkers is crucial for patient selection in these novel treatment strategies.

Area of Science:

  • Oncology
  • Immunology
  • Gastroenterology

Background:

  • Advanced gastric cancer has a poor prognosis despite conventional treatments.
  • Immune checkpoint inhibitors, specifically targeting PD-1/PD-L1, are effective in other solid tumors.
  • The PD-1/PD-L1 axis represents a potential therapeutic target for gastric cancer.

Purpose of the Study:

  • To review the role of the immune microenvironment in gastric tumors.
  • To evaluate the efficacy of PD-1/PD-L1 blockade in gastric cancer.
  • To discuss predictive biomarkers for anti-tumor response.

Main Methods:

  • Review of scientific literature on gastric cancer immunology.
  • Analysis of clinical trial data for anti-PD-1/PD-L1 therapies.
  • Examination of biomarkers such as PD-L1 expression and mismatch repair status.

Main Results:

  • The immune microenvironment of gastric tumors influences PD-1/PD-L1 axis efficacy.
  • Clinical trials show encouraging results for PD-1/PD-L1 inhibitors in various treatment settings.
  • Biomarker expression (PD-L1, MMR) correlates with treatment outcomes.

Conclusions:

  • Immunotherapy, particularly PD-1/PD-L1 blockade, holds promise for advanced gastric cancer.
  • Combination strategies and monotherapy may benefit specific patient subgroups.
  • Further research is needed to identify and validate predictive biomarkers for optimal patient selection.
Keywords:
Advanced gastric cancerCTLA-4ImmunotherapyPD-1PD-L1

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