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High amylase resistant starch to decrease stool output in people with short bowel syndrome: A pilot trial.

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This summary is machine-generated.

High Amylase Resistant Starch (HARS) supplementation significantly reduced stool output in patients with short bowel syndrome (SBS). This dietary intervention offers a promising approach to managing diarrhoea in SBS patients.

Keywords:
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Area of Science:

  • Gastroenterology
  • Nutritional Science
  • Clinical Research

Background:

  • Short bowel syndrome (SBS) is characterized by malabsorptive diarrhea and dehydration, often refractory to conventional treatments.
  • High Amylase Resistant Starch (HARS) has demonstrated efficacy in reducing diarrhea from various causes.
  • The mechanism for HARS in SBS is hypothesized to involve short-chain fatty acid production, enhancing water absorption.

Purpose of the Study:

  • To investigate the efficacy of dietary High Amylase Resistant Starch (HARS) in reducing stool output in patients with Short Bowel Syndrome (SBS).

Main Methods:

  • A 2-week crossover trial involving adult patients with SBS and colon in continuity.
  • Participants consumed their usual diet (control) and a diet supplemented with 50g HARS.
  • Daily stool weight and bowel action frequency were measured and compared between conditions.

Main Results:

  • Five out of eight recruited adults completed the trial.
  • Mean daily stool output significantly decreased from 1049 g/d to 804 g/d (p=0.023) with HARS supplementation.
  • A trend towards reduction in the number of daily bowel actions was observed.

Conclusions:

  • Dietary HARS shows potential in reducing stool output for patients with Short Bowel Syndrome (SBS).
  • Further research with longer trial durations is necessary to validate these findings and assess impacts on nutritional and hydration status.