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Prion Protein Antagonists Rescue Alzheimer's Amyloid-β-Related Cognitive Deficits
Abhay P Sagare1, Melanie D Sweeney1, Amy R Nelson1
1Department of Physiology and Neuroscience, Zilkha Neurogenetic Institute, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA; These authors contributed equally to this work.
Trends in Molecular Medicine
|January 22, 2019
Abstract:
Recent studies revealed that cellular prion protein on neurons bind Alzheimer's amyloid-β oligomers, causing neurotoxic effects. A new article in Cell Reports by Gunther and colleagues (Cell Rep. 2019; 26:145-158) shows that an orally administered cellular prion protein antagonist can rescue synaptic and cognitive deficits in Alzheimer's mice overexpressing amyloid-β.