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Kidney Transplantation in Elderly Recipients: A Single-Center Experience
G L Adani1, U Baccarani1, S Crestale1
1Department of Medicine, Kidney & Liver Transplantation Academic University Hospital, P. le S.M della Misericordia, Udine, Italy.
Transplantation Proceedings
|January 22, 2019
Summary
Kidney transplants in older adults (>65 years) show good graft survival. However, mortality increases significantly in recipients over 71, with infections and tumors being leading causes of death.
Area of Science:
- Nephrology
- Transplantation Immunology
- Geriatric Medicine
Background:
- Kidney transplantation is a vital treatment for end-stage renal disease.
- Assessing outcomes in elderly recipients is crucial for treatment optimization.
Purpose of the Study:
- To evaluate patient and graft survival after kidney transplant in recipients over 65 years old.
- To identify causes of death and risk factors for mortality in this population.
Main Methods:
- Retrospective analysis of 109 first single kidney transplants in recipients aged 65+ (1993-2016).
- Comparison of two age groups (65-70 vs. 71-76 years).
- Analysis of donor/recipient characteristics, ischemia times, delayed graft function, acute rejection, and causes of death.
Main Results:
- Overall patient survival at 1, 3, 5, and 10 years was 89%, 84%, 72%, and 45%.
- Overall graft survival at 1, 3, 5, and 10 years was 100%, 97%, 89%, and 84%.
- Mortality was higher in the 71-76 age group (P=.006), with infections and tumors as primary causes of death.
Conclusions:
- Kidney transplantation is safe and feasible in patients over 65, offering good graft survival.
- Increased mortality is observed in recipients older than 71 years.
- Delayed graft function is a significant risk factor for mortality.
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