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Ayurvedic polyherbal combination (PDBT) for prediabetes: A randomized double blind placebo controlled study
Amit Nakanekar1, Kuldip Kohli2, Pratima Tatke3
1Government Ayurvedic College, Nagpur, India.
Journal of Ayurveda and Integrative Medicine
|January 22, 2019
Summary
A polyherbal combination (PDBT) with lifestyle changes significantly reduced type 2 diabetes mellitus (DM) progression in prediabetics. This natural intervention lowered diabetes conversion by 47% with no adverse effects.
Area of Science:
- Endocrinology
- Pharmacology
- Preventive Medicine
Background:
- Type 2 diabetes mellitus (DM) prevalence is rising globally, straining healthcare systems.
- Prediabetes represents a critical stage for intervention to prevent full DM.
- Early intervention in prediabetes can halt or slow disease progression.
Purpose of the Study:
- To evaluate a polyherbal combination (PDBT) plus lifestyle modification for DM prevention in prediabetics.
- To compare PDBT and lifestyle management against a placebo and lifestyle management.
Main Methods:
- A 6-month, double-blind, placebo-controlled randomized clinical trial.
- 114 prediabetic participants were randomized into PDBT + lifestyle management or placebo + lifestyle management groups.
- The intervention group received 2g/day of PDBT.
Main Results:
- The PDBT group showed a 47% risk reduction in conversion to DM compared to placebo.
- Significant reductions in fasting/postprandial blood glucose, HbA1c, fasting insulin, and HOMA-IR were observed in the PDBT group.
- No significant changes in BMI or reported adverse effects were noted.
Conclusions:
- PDBT combined with lifestyle modification effectively reduces DM conversion in prediabetic individuals.
- This polyherbal approach offers a safe and effective strategy for diabetes prevention.
- The findings support PDBT as a valuable adjunct to lifestyle changes for managing prediabetes.
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