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Risk of Stroke among Patients with Chronic Rhinosinusitis: A Systematic Review and Meta-analysis

Phuuwadith Wattanachayakul1, Pongprueth Rujirachun1, Patompong Ungprasert2

  • 1Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.

Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association
|January 22, 2019
PubMed

Insights

Patients with chronic rhinosinusitis (CRS) have a significantly higher risk of stroke. Further research is needed to confirm causality and guide clinical practice for this association.

Area of Science:

  • Medical research
  • Epidemiology
  • Clinical practice

Background:

  • Emerging evidence suggests a potential link between chronic rhinosinusitis (CRS) and increased stroke risk.
  • Existing data are limited, necessitating a comprehensive analysis to clarify this association.

Purpose of the Study:

  • To systematically review and meta-analyze existing studies on the relationship between CRS and stroke.
  • To quantify the risk of stroke in patients diagnosed with CRS.

Main Methods:

  • A systematic literature search was performed in MEDLINE and EMBASE databases up to October 2018.
  • Included observational studies compared stroke risk in CRS patients versus controls.
  • Random-effects meta-analysis calculated pooled risk ratios (RR) and 95% confidence intervals (CI).

Main Results:

  • Five studies encompassing 447,065 participants were included in the meta-analysis.
  • Patients with CRS exhibited a significantly elevated risk of stroke.
  • The pooled RR for stroke in CRS patients was 1.79 (95% CI: 1.34-2.40), with substantial heterogeneity (I²=84%).

Conclusions:

  • Chronic rhinosinusitis is associated with an increased risk of stroke.
  • The causal nature of this association requires further investigation.
  • Clinical implications for managing CRS patients at risk of stroke warrant additional study.
Abstract

Keywords:
Strokechronic rhinosinusitismeta-analysisrisk factor

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