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Joint replacement in X-linked hypophosphatemia.
Emily S Mills1, Louis Iorio1, Richard S Feinn1
1Department of Medical Sciences, Frank H. Netter MD School of Medicine at Quinnipiac University, Hamden, CT, 06518, USA.
Journal of Orthopaedics
|January 22, 2019
Summary
Total joint arthroplasty significantly benefits patients with X-linked hypophosphatemia (XLH) by improving function and addressing severe osteoarthritis. This study confirms its positive impact on joint health in XLH individuals.
Area of Science:
- Orthopedics
- Genetics
- Rheumatology
Background:
- X-linked hypophosphatemia (XLH) is characterized by severe, degenerative osteoarthritis.
- XLH's impact on joint health necessitates effective treatment strategies.
Purpose of the Study:
- To evaluate the effectiveness of total joint arthroplasty in patients with X-linked hypophosphatemia.
- To assess functional outcomes following knee and hip arthroplasty in XLH patients.
Main Methods:
- Retrospective chart review and patient survey.
- Utilized Knee or Hip Osteoarthritis Outcome Score Physical Function Short Form (KOOS-PS and HOOS-PS).
- Included 14 total knee arthroplasties and 7 total hip arthroplasties in 11 XLH patients.
Main Results:
- Mean KOOS-PS score was 31.4 ± 9.7 after 6.9 years follow-up.
- Mean HOOS-PS score was 14.8 ± 12.9 after 7.6 years follow-up.
- Low complication rates: one aseptic loosening (knee), one revision for polyethylene wear (hip).
Conclusions:
- Total joint arthroplasty demonstrates significant benefits for XLH patients.
- Arthroplasty effectively manages severe osteoarthritis associated with X-linked hypophosphatemia.
- Positive functional outcomes support arthroplasty as a beneficial intervention for XLH-related joint disease.
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