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Tuning the Protein Phosphorylation by Receptor Type Protein Tyrosine Phosphatase Epsilon (PTPRE) in Normal and Cancer

Jinping Liang1,2, Jun Shi1, Na Wang1

  • 1School of Basic Medical Sciences, Ningxia Medical University, Yinchuan, P.R.China.

Journal of Cancer
|January 22, 2019
PubMed

Insights

Receptor type protein tyrosine phosphatase epsilon (PTPRE) regulates cell signaling. This review summarizes PTPRE

Area of Science:

  • Biochemistry and Molecular Biology
  • Cellular Signaling
  • Enzymology

Background:

  • Tyrosine phosphorylation, regulated by tyrosine kinases and phosphatases, is a critical post-translational modification.
  • Imbalances in tyrosine kinase and phosphatase activity are implicated in various diseases.
  • Receptor type protein tyrosine phosphatase epsilon (PTPRE) is closely related to PTPRA and plays diverse roles across tissues.

Purpose of the Study:

  • To review the current understanding of PTPRE's role in cellular signal transduction.
  • To summarize the functions of PTPRE in both normal physiological and pathological states.
  • To highlight PTPRE's involvement in different cell types, including osteoclasts, neurons, and hematopoietic and cancer cells.

Main Methods:

  • Literature review and synthesis of existing research on PTPRE.
  • Analysis of studies investigating PTPRE's impact on cellular signaling pathways.
  • Compilation of data on PTPRE's functions in various cell types and disease contexts.

Main Results:

  • PTPRE is involved in regulating diverse cellular processes through signal transduction.
  • PTPRE exhibits distinct functions depending on the cellular environment and tissue type.
  • Dysregulation of PTPRE is associated with various pathological conditions.

Conclusions:

  • PTPRE is a significant regulator of cellular signaling with implications in health and disease.
  • Further research into PTPRE's mechanisms and functions is warranted.
  • Understanding PTPRE's role can provide insights into potential therapeutic strategies for related diseases.
Keywords:
PTPREcancersignalingtyrosine phosphatase

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