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Murine Fecal Isolation and Microbiota Transplantation
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Organ transplantation and gut microbiota: current reviews and future challenges

Jie Xiao1,2, Zhao Peng3,4, Yuxiao Liao3,4

  • 1Department of Cardiovascular Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology Wuhan 430022, Hubei, China.

American Journal of Translational Research
|January 22, 2019
PubMed

Insights

Gut microbiota alterations impact organ transplant outcomes. Novel therapies like fecal microbiota transplantation (FMT), probiotics, and prebiotics show promise for improving post-transplant health and prognosis.

Area of Science:

  • Microbiology
  • Immunology
  • Transplantation Science

Background:

  • Organ transplantation is a critical treatment for end-stage organ failure.
  • Post-transplantation complications pose significant health risks.
  • The gut microbiota plays a vital role in host health, including immune regulation and metabolism.

Purpose of the Study:

  • To review the relationship between gut microbiota and organ transplantation.
  • To explore the potential of novel therapies like fecal microbiota transplantation (FMT), probiotics, and prebiotics in post-transplant care.
  • To suggest future research directions in this field.

Main Methods:

  • Literature review of studies investigating gut microbiota in organ transplant patients.
  • Analysis of research on the functions of the intestinal microbiome.
  • Examination of emerging therapeutic strategies such as FMT, probiotics, and prebiotics.

Main Results:

  • Significant alterations in the gut microbiome are observed in organ transplant recipients compared to pre-transplant states.
  • The gut microbiota influences various host functions crucial for transplant success.
  • Fecal microbiota transplantation (FMT), probiotics, and prebiotics have demonstrated efficacy in other diseases and may be applicable to transplantation.

Conclusions:

  • Gut microbiota composition is altered after organ transplantation and may serve as a prognostic indicator.
  • Emerging therapies targeting the gut microbiota, including FMT, probiotics, and prebiotics, offer potential for improving transplant outcomes.
  • Further research is warranted to fully understand and leverage the gut microbiota in organ transplantation.
Keywords:
Organ transplantationcomplicationfecal microbiota transplantationgut microbiotaprebioticprobioticprognosis

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