Related Experiment Video
Updated: Jan 30, 2026
05:06
A "Patient-Like" Orthotopic Syngeneic Mouse Model of Hepatocellular Carcinoma Metastasis
Published on: October 24, 2015
12.8K
Diosgenin increased DDX3 expression in hepatocellular carcinoma
Hong Yu1, Yuanni Liu1, Chuanzhen Niu1
1Department of Liver Disease, Yantai Infectious Diseases Hospital Yantai, Shandong, China.
American Journal of Translational Research
|January 22, 2019
Summary
Diosgenin exhibits potent anti-cancer effects against liver cancer by inhibiting cell proliferation and promoting cell death. This study reveals diosgenin
Area of Science:
- Oncology
- Molecular Biology
- Pharmacology
Background:
- Liver cancer is a major global health concern and a leading cause of cancer-related mortality.
- Diosgenin possesses known bioactivities and pharmaceutical applications, including anti-cancer properties.
- DEAD box polypeptide 3 (DDX3) is implicated in cancer development, but its specific role in hepatocellular carcinoma (HCC) requires further elucidation.
Purpose of the Study:
- To investigate the anti-tumor effects of diosgenin on human hepatocellular carcinoma (HCC) cells.
- To determine the involvement of DDX3 in the anti-cancer activity of diosgenin in HCC.
Main Methods:
- Cell proliferation assays were performed to assess diosgenin's impact on HCC cell growth.
- Apoptosis, cell cycle progression (G2/M phase arrest), migration, and invasion assays were conducted.
- DDX3 expression levels were measured in response to diosgenin treatment.
Main Results:
- Diosgenin significantly inhibited HCC cell proliferation and suppressed migration and invasion.
- Diosgenin induced apoptotic cell death and caused G2/M phase arrest in HCC cells.
- DDX3 expression was notably upregulated following diosgenin exposure.
Conclusions:
- Diosgenin demonstrates significant cytotoxic effects against HCC cells.
- Diosgenin exhibits potential therapeutic value for treating liver cancer.
- The study suggests DDX3 may play a role in diosgenin's anti-HCC mechanisms.
Related Concept Videos
01:18Increasing Function
391
An increasing function exhibits a rise in output values as input values increase. This behavior is depicted graphically as a curve or line that slopes upward from left to right. Such a function satisfies the condition that if x1 < x2, then f(x1) < f(x2), indicating that the function values grow with increasing inputs. This concept is fundamental in understanding growth trends across various domains, such as population dynamics, financial investments, or resource consumption.The...
391
01:25Increased Body Temperature
7.5K
A body temperature above 38°C (100.4 °F) is known as fever or pyrexia, and a person with fever is termed 'febrile.' Typically, the hypothalamus, a part of the brain that acts as the body's thermostat, regulates body temperature through a thermoregulatory setpoint. It receives signals from cold and warm thermal receptors throughout the body and adjusts the body's temperature accordingly. Fever occurs when this hypothalamic setpoint is altered, usually in...
7.5K
01:17Increased pulse rate
1.2K
Tachycardia is a condition marked by an abnormally fast or irregular heart rate, surpassing the typical resting rate. In adults, tachycardia is characterized by a pulse rate ranging from 100 to 180 beats per minute. The increased heart rate can result in inadequate blood flow to various body parts, ultimately diminishing the oxygen supply to organs and tissues.
Many factors can elevate the risk of developing tachycardia. These include advanced age, a family history of arrhythmias, and an...
Many factors can elevate the risk of developing tachycardia. These include advanced age, a family history of arrhythmias, and an...
1.2K
02:35Chromatin Position Affects Gene Expression
24.8K
Chromatin is the massive complex of DNA and proteins packaged inside the nucleus. The complexity of chromatin folding and how it is packaged inside the nucleus greatly influences access to genetic information. Generally, the nucleus' periphery is considered transcriptionally repressive, while the cell's interior is considered a transcriptionally active area.
Topologically Associated Domains (TADs)
The 3-dimensional positioning of chromatin in the nucleus influences the...
Topologically Associated Domains (TADs)
The 3-dimensional positioning of chromatin in the nucleus influences the...
24.8K
01:42What is Gene Expression?
196.6K
Overview
Gene expression is the process in which DNA directs the synthesis of functional products, that is, proteins. Cells can regulate gene expression at various stages. It allows organisms to generate different cell types and enables cells to adapt to internal and external factors.
Genetic Information Flows from DNA to RNA to Protein
A gene is a stretch of DNA that serves as the blueprint for functional RNAs and proteins. Since DNA is made up of nucleotides and proteins consist of amino...
Gene expression is the process in which DNA directs the synthesis of functional products, that is, proteins. Cells can regulate gene expression at various stages. It allows organisms to generate different cell types and enables cells to adapt to internal and external factors.
Genetic Information Flows from DNA to RNA to Protein
A gene is a stretch of DNA that serves as the blueprint for functional RNAs and proteins. Since DNA is made up of nucleotides and proteins consist of amino...
196.6K
01:36What is Gene Expression?
11.4K
A gene is a stretch of DNA that serves as the blueprint for functional RNAs and proteins. Since DNA is comprised of nucleotides and proteins are comprised of amino acids, a mediator is required to convert the information encoded in DNA into proteins. This mediator is the messenger RNA (mRNA). mRNA copies the blueprint from DNA by a process called transcription. In eukaryotes, transcription occurs in the nucleus by complementary base-pairing with the DNA template. The mRNA is then...
11.4K