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Diosgenin increased DDX3 expression in hepatocellular carcinoma

Hong Yu1, Yuanni Liu1, Chuanzhen Niu1

  • 1Department of Liver Disease, Yantai Infectious Diseases Hospital Yantai, Shandong, China.

American Journal of Translational Research
|January 22, 2019
PubMed

Insights

Diosgenin exhibits potent anti-cancer effects against liver cancer by inhibiting cell proliferation and promoting cell death. This study reveals diosgenin

Area of Science:

  • Oncology
  • Molecular Biology
  • Pharmacology

Background:

  • Liver cancer is a major global health concern and a leading cause of cancer-related mortality.
  • Diosgenin possesses known bioactivities and pharmaceutical applications, including anti-cancer properties.
  • DEAD box polypeptide 3 (DDX3) is implicated in cancer development, but its specific role in hepatocellular carcinoma (HCC) requires further elucidation.

Purpose of the Study:

  • To investigate the anti-tumor effects of diosgenin on human hepatocellular carcinoma (HCC) cells.
  • To determine the involvement of DDX3 in the anti-cancer activity of diosgenin in HCC.

Main Methods:

  • Cell proliferation assays were performed to assess diosgenin's impact on HCC cell growth.
  • Apoptosis, cell cycle progression (G2/M phase arrest), migration, and invasion assays were conducted.
  • DDX3 expression levels were measured in response to diosgenin treatment.

Main Results:

  • Diosgenin significantly inhibited HCC cell proliferation and suppressed migration and invasion.
  • Diosgenin induced apoptotic cell death and caused G2/M phase arrest in HCC cells.
  • DDX3 expression was notably upregulated following diosgenin exposure.

Conclusions:

  • Diosgenin demonstrates significant cytotoxic effects against HCC cells.
  • Diosgenin exhibits potential therapeutic value for treating liver cancer.
  • The study suggests DDX3 may play a role in diosgenin's anti-HCC mechanisms.
Keywords:
DDX3diosgeninhepatocellular carcinomainvasionproliferation

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