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Inhibitor of DNA binding proteins: implications in human cancer progression and metastasis

Jing Ke1,2, Ruolin Wu3,2, Yong Chen4

  • 1Department of Liver Disease, The Fourth Affiliated Hospital of Anhui Medical University Hefei 230022, China.

American Journal of Translational Research
|January 22, 2019
PubMed

Insights

Inhibitor of DNA binding (ID) proteins regulate key cancer processes. Targeting these proteins offers a promising strategy for effective anticancer therapy.

Area of Science:

  • Molecular Biology
  • Oncology
  • Genetics

Background:

  • Inhibitor of DNA binding (ID) proteins are helix-loop-helix (HLH) transcription factors.
  • They function as dominant-negative regulators by forming non-functional heterodimers with other basic HLH proteins.
  • Aberrant ID protein expression is linked to various cancers and poor prognosis.

Purpose of the Study:

  • To review the biological functions and signaling pathways of ID proteins.
  • To discuss the regulation of ID proteins in cancer progression and metastasis.
  • To explore ID protein expression profiles and their prognostic implications in cancer.

Main Methods:

  • Literature review of ID protein functions in cancer.
  • Analysis of signaling pathways affiliated with ID proteins.
  • Examination of expression profiles and therapeutic targeting strategies.

Main Results:

  • ID proteins are crucial in cell differentiation, cell cycle, migration, EMT, angiogenesis, stemness, chemoresistance, tumorigenesis, and metastasis.
  • Their dysregulation is observed in numerous human cancers, correlating with advanced stages and adverse outcomes.
  • Therapeutic targeting of ID proteins presents a viable anticancer approach.

Conclusions:

  • ID proteins play multifaceted roles in cancer development and progression.
  • Understanding their regulation and expression is vital for predicting patient outcomes.
  • Targeting ID proteins holds significant promise for novel cancer treatments.
Keywords:
Inhibitor of DNA binding proteincancer progressioncancer stem cellscancer therapymetastasis

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