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Related Experiment Video

Updated: Jan 30, 2026

Experimental Methods to Study Human Postural Control
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NIH Policies on Experimental Studies with Humans.

William T Riley1, Melissa Riddle1, Michael Lauer1

  • 1National Institutes of Health.

Nature Human Behaviour
|January 22, 2019
PubMed
Summary
This summary is machine-generated.

New U.S. National Institutes of Health policies mandate clinical trials registration on ClinicalTrials.gov, specific grant applications, and Good Clinical Practice training for human experimental studies.

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Area of Science:

  • Biomedical Research
  • Clinical Research Policy
  • Regulatory Science

Background:

  • The U.S. National Institutes of Health (NIH) oversees a significant portion of biomedical research funding and policy.
  • Clinical trials involving human subjects are a critical component of medical advancement.
  • Ensuring the integrity and transparency of clinical trials is paramount.

Purpose of the Study:

  • To inform researchers and institutions about the updated U.S. National Institutes of Health (NIH) policies for clinical trials.
  • To outline the mandatory requirements for studies involving experimental manipulations of humans.
  • To ensure compliance with new federal regulations for clinical research.

Main Methods:

  • Policy dissemination and communication.
  • Requirement for registration and reporting on ClinicalTrials.gov.
  • Mandatory grant application procedures under specific funding announcements.
  • Implementation of Good Clinical Practice (GCP) training for all investigators.

Main Results:

  • All studies involving experimental manipulations of humans will be subject to NIH clinical trials policies.
  • Registration and reporting in ClinicalTrials.gov are compulsory.
  • Grant applications must adhere to specific NIH clinical trials funding opportunity announcements.
  • Investigators are required to complete Good Clinical Practice training.

Conclusions:

  • The NIH has established comprehensive policies for clinical trials involving human experimental manipulations.
  • Compliance involves registration, specific grant submissions, and mandatory GCP training.
  • These policies aim to enhance the quality, transparency, and ethical conduct of clinical research funded by the NIH.