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Published on: March 13, 2018
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Neurological disorders are associated with bullous pemphigoid
E Papakonstantinou1, M M Limberg2, M Gehring1
1Department of Dermatology and Allergy, Hannover Medical School, Hannover, Germany.
Summary
Bullous pemphigoid (BP), a blistering disease, is significantly associated with neurological disorders like dementia, Parkinson's disease, and stroke, particularly in the elderly. Further research is needed to understand the underlying immunological links.
Area of Science:
- Dermatology
- Neurology
- Immunology
Background:
- Bullous pemphigoid (BP) is the most common autoimmune blistering disease, affecting the elderly.
- Recent studies suggest a link between BP and various neurological conditions.
Purpose of the Study:
- To investigate the association between bullous pemphigoid and neurological disorders.
- Study conducted at a single center in Germany.
Main Methods:
- Retrospective analysis of 183 BP patients diagnosed between 2011-2015.
- Comparison with 348 age- and sex-matched control individuals.
- Neurological disorders confirmed by specialists.
Main Results:
- A statistically significant association was found between BP and neurological disorders (P < 0.0001).
- Specific associations included dementia (P < 0.0001), Parkinson's disease (P = 0.0434), and stroke (P = 0.0015).
- Alzheimer's disease was more prevalent in the control group.
Conclusions:
- The study confirms a significant link between bullous pemphigoid and neurological disorders such as dementia, Parkinson's disease, and stroke.
- These findings highlight the need for further research into the immunological mechanisms connecting these conditions.
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