Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Pituitary-thyroid relationships in hypothyroidism.

J E Silva

    Bailliere'S Clinical Endocrinology and Metabolism
    |August 1, 1988
    PubMed
    Summary
    This summary is machine-generated.

    The pituitary gland is a key target for thyroid hormone, influencing thyroid-stimulating hormone (TSH) secretion and impacting hypothyroidism treatment. Understanding these thyroid hormone effects on the pituitary is crucial for managing complex clinical presentations.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Primary Abdominal Ectopic Pregnancy. Case Report.

    Journal of minimally invasive gynecology·2016
    Same author

    Accessory Trocar Site Herniation. A Case Report.

    Journal of minimally invasive gynecology·2016
    Same author

    Stick-slip water penetration into capillaries coated with swelling hydrogel.

    Soft matter·2015
    Same author

    Metabolic and neuroendocrine responses to Roux-en-Y gastric bypass. I: energy balance, metabolic changes, and fat loss.

    The Journal of clinical endocrinology and metabolism·2012
    Same author

    Type-2 iodothyronine 5'deiodinase (D2) in skeletal muscle of C57Bl/6 mice. II. Evidence for a role of D2 in the hypermetabolism of thyroid hormone receptor alpha-deficient mice.

    Endocrinology·2011
    Same author

    Type-2 iodothyronine 5'deiodinase in skeletal muscle of C57BL/6 mice. I. Identity, subcellular localization, and characterization.

    Endocrinology·2011

    Area of Science:

    • Endocrinology
    • Molecular Biology
    • Physiology

    Background:

    • The pituitary gland is a primary target for thyroid hormone action.
    • It possesses high-density triiodothyronine (T3) receptors and Type II 5' deiodinase activity, crucial for regulating thyroid-stimulating hormone (TSH) and other pituitary hormones.
    • Thyroid hormone's influence on the pituitary impacts the understanding and treatment of hypothyroidism.

    Purpose of the Study:

    • To elucidate the multifaceted consequences of the pituitary gland being a target tissue for thyroid hormones.
    • To explore the direct and indirect effects of thyroid hormone on various pituitary hormone secretions.
    • To understand how pituitary hormone interactions contribute to the clinical variability of hypothyroidism.

    Main Methods:

    Related Experiment Videos

  • Review of existing literature on thyroid hormone action in the pituitary.
  • Analysis of the role of T3 receptors and deiodinase activity in pituitary hormone regulation.
  • Examination of the impact of thyroid hormone on the secretion of TSH and other pituitary hormones.

    • Main Results:

    • Thyroid hormone (T3) directly affects multiple pituitary secretions.
    • Thyroid hormone influences other pituitary hormones directly or indirectly.
    • These pituitary effects contribute significantly to the diverse clinical manifestations of hypothyroidism.

    Conclusions:

    • The pituitary gland's role as a thyroid hormone target has significant implications for understanding hypothyroidism.
    • Variability in pituitary hormone function contributes to diagnostic and therapeutic challenges in hypothyroidism.
    • Identifying and treating life-threatening pituitary abnormalities unresponsive to standard thyroid hormone replacement is essential.