Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Neonatal hypothyroidism: recent developments.

F Delange

    Bailliere'S Clinical Endocrinology and Metabolism
    |August 1, 1988
    PubMed
    Summary
    This summary is machine-generated.

    This study reviews congenital hypothyroidism (CH) and transient neonatal hypothyroidism, highlighting screening, diagnosis, and treatment. Early intervention with levothyroxine (LT4) ensures excellent neurodevelopmental outcomes for most infants with CH.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Prevention and control of iodine deficiency in pregnant and lactating women and in children less than 2-years-old: conclusions and recommendations of the Technical Consultation.

    Public health nutrition·2008
    Same author

    Epidemiology and impact of iodine deficiency in pediatrics.

    Journal of pediatric endocrinology & metabolism : JPEM·2006
    Same author

    Thyroid fetomaternal relationship in iodine deficiency.

    Forum of nutrition·2005
    Same author

    Iodine supplementation of pregnant women in Europe: a review and recommendations.

    European journal of clinical nutrition·2004
    Same author

    Prevalence of iodine deficiency worldwide.

    Lancet (London, England)·2004
    Same author

    The elimination of iodine deficiency in the Czech Republic: the steps toward success.

    Thyroid : official journal of the American Thyroid Association·2004
    Same journal

    Phytoestrogen content in foods.

    Bailliere's clinical endocrinology and metabolism·1999
    Same journal

    Soyfoods, isoflavones and risk of colonic cancer: a review of the in vitro and in vivo data.

    Bailliere's clinical endocrinology and metabolism·1999
    Same journal

    Experimental studies on lignans and cancer.

    Bailliere's clinical endocrinology and metabolism·1999
    Same journal

    Reproductive actions of phytoestrogens.

    Bailliere's clinical endocrinology and metabolism·1999
    Same journal

    Phytoestrogens and inhibition of angiogenesis.

    Bailliere's clinical endocrinology and metabolism·1999
    Same journal

    Phytoestrogens and diseases of the prostate gland.

    Bailliere's clinical endocrinology and metabolism·1999
    See all related articles

    Area of Science:

    • Endocrinology
    • Neonatology
    • Pediatric Genetics

    Background:

    • Congenital hypothyroidism (CH) is detected via neonatal screening, with varying incidence globally.
    • The etiology of CH is multifactorial, potentially involving genetic and environmental factors, with ongoing research into autoimmunity.
    • Transient neonatal hypothyroidism can stem from iodine imbalance or maternal antibodies.

    Purpose of the Study:

    • To summarize recent advancements in sporadic CH and transient neonatal hypothyroidism.
    • To discuss diagnostic methods and their relation to long-term prognosis.
    • To outline current therapeutic strategies and their impact on neurodevelopmental outcomes.

    Main Methods:

    • Review of current literature on CH and transient neonatal hypothyroidism.

    Related Experiment Videos

  • Analysis of diagnostic tools including clinical signs, bone maturation, serum T4, thyroid scintigraphy, echography, and serum Tg.
  • Evaluation of treatment protocols using levothyroxine (LT4) and monitoring of thyroid-stimulating hormone (TSH).

    • Main Results:

    • CH incidence is approximately 1 in 4000 births in Western countries, lower in Japan.
    • Thyroid echography aids in diagnosis but cannot precisely define dysgenesis.
    • Adequate LT4 therapy and a supportive environment lead to excellent neurodevelopmental outcomes, though severe prenatal hypothyroidism may impact IQ.
    • Transient hypothyroidism in newborns is often linked to iodine levels or maternal TSH binding inhibitor immunoglobulins (TBII).

    Conclusions:

    • Early diagnosis and appropriate LT4 therapy are crucial for optimal neurodevelopmental outcomes in CH.
    • Monitoring serum T4 and TSH is essential to ensure adequate treatment and avoid persistent hyperthyrotropinaemia.
    • Understanding the causes of transient neonatal hypothyroidism is important for managing affected newborns, especially in iodine-deficient regions.