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[DIRECT ADMISSION OF STEMI PATIENTS TO THE CARDIAC CARE UNIT VERSUS ADMISSION VIA THE EMERGENCY DEPARTMENT FOR
Simcha R Meisel1, Michael Kleiner-Shochat1, Aaron Frimerman1
1Heart Institute, Hillel Yaffe Medical Center, Hadera, Israel, affiliated to the Bruce Rappaport School of Medicine, Technion-Israel Institute of Technology, Haifa - Israel.
Insights
Directly admitting ST-elevation myocardial infarction (STEMI) patients to the cardiac care unit (CCU) for primary percutaneous coronary intervention (PPCI) significantly reduces door-to-balloon times and improves both short- and long-term survival rates.
Area of Science:
- Cardiology
- Emergency Medicine
- Interventional Cardiology
Background:
- Timely reperfusion is critical for limiting myocardial damage in ST-elevation myocardial infarction (STEMI) patients.
- Primary percutaneous coronary intervention (PPCI) is the preferred reperfusion strategy.
- Direct admission to the cardiac care unit (CCU) may expedite treatment.
Purpose of the Study:
- To compare the characteristics and mortality of STEMI patients undergoing PPCI who were directly admitted to the CCU versus those admitted via the emergency department (ED).
Main Methods:
- A registry-based comparison of 730 consecutive STEMI patients treated with PPCI.
- 303 patients were directly admitted to the CCU, while 427 were admitted via the ED.
- Analysis included demographic data, medical history, risk factors, time intervals, and short- and long-term mortality.
Main Results:
- Direct CCU admission was associated with significantly shorter pain-to-CCU and door-to-balloon times compared to ED admission.
- Left ventricular ejection fraction (LVEF) and creatine kinase (CK) levels were similar between groups.
- 30-day, one-year, and long-term mortality rates were significantly lower in patients directly admitted to the CCU.
- Longer pain-to-balloon times correlated with increased long-term mortality.
Conclusions:
- Direct CCU admission for STEMI patients undergoing PPCI improves adherence to guideline-recommended door-to-balloon times.
- This strategy leads to superior short- and long-term survival outcomes.
- Reducing overall pain-to-balloon time is crucial for improving patient prognosis.
Introduction:
Shortening door-to-balloon time intervals in ST-elevation myocardial infarction (STEMI) patients treated by primary percutaneous coronary intervention (PPCI) is necessary in order to limit myocardial damage. Direct admission to the cardiac care unit (CCU) facilitates this goal. We compared characteristics and short- and long-term mortality of PPCI-treated STEMI patients admitted directly to the CCU with those admitted via the emergency department (ED).
Methods:
To compare 303 patients admitted directly to the CCU (42%) with 427 admitted via the ED (58%) included in the current registry comprising 730 consecutive PPCI-treated STEMI patients.
Results:
Groups were similar regarding demographics, medical history and risk factors. Pain-to-CCU time was 151±164 minutes (median-94) for patients admitted directly and 242±226 minutes (160) for those admitted via the ED, while door-to-balloon intervals were 69±42 minutes (61) and 133±102 minutes (111), respectively. LVEF evaluated during admission (48.3±13% [47.5%] vs. 47.7±13.7% [47.5%]) and mean CK level (893±1157 [527] vs. 891±1255 [507], p=0.45) were similar between groups. Mortality was 4.2% vs. 10.3% at 30-days (p<0.002), 7.6% and 14.3% at one-year (p<0.01), reaching 12.2% and 21.9% at 3.9±2.3 years (median-3.5, p<0.004) among directly-admitted patients vs. those admitted via the ED, respectively. Long-term mortality was 4.1%, 9.4%, 21.4%, and 16% for pain-to-balloon quartiles of <140 min, 141-207 min, 208-330 min, and >330 mins, respectively (p=0.026).
Conclusions:
Direct admission of STEMI patients to the CCU for PPCI facilitated the attainment of guidelines-dictated door-to-balloon time intervals and yielded improved short- and long-term mortality. Longer pain-to-balloon time was associated with higher long-term mortality.
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