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Comprehensive Autopsy Program for Individuals with Multiple Sclerosis
Published on: July 19, 2019
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Association between pathological and MRI findings in multiple sclerosis.
Massimo Filippi1, Wolfgang Brück2, Declan Chard3
1Neuroimaging Research Unit and Department of Neurology, Institute of Experimental Neurology, Division of Neuroscience, San Raffaele Scientific Institute, Vita-Salute San Raffaele University, Milan, Italy.
The Lancet. Neurology
|January 22, 2019
Summary
Pathological evaluation is key for understanding multiple sclerosis (MS) and developing treatments. Advanced MRI techniques show promise in monitoring MS pathology and disease progression, but further research is needed.
Area of Science:
- Neurology
- Radiology
- Pathology
Background:
- Pathological evaluation is the gold standard for understanding multiple sclerosis (MS) but has limitations.
- Magnetic resonance imaging (MRI) shows sensitivity to MS pathological substrates like inflammation, demyelination, and neuro-axonal loss.
Purpose of the Study:
- To explore the role of MRI in evaluating various pathological processes in MS.
- To highlight advancements in MRI for diagnosing and monitoring MS.
- To identify emerging questions regarding pathological interactions and remyelination in MS.
Main Methods:
- Correlative studies linking MRI findings with pathological substrates.
- Investigation of MRI's role in assessing leptomeningeal involvement, central vein and rim of lesions, microstructural abnormalities, iron accumulation, and recovery mechanisms.
- Review of current techniques for quantifying CNS pathological processes in MS.
Main Results:
- MRI is sensitive to key pathological substrates of MS.
- MRI is being investigated for its role in evaluating diverse pathological aspects, including novel targets.
- Quantification techniques have advanced MS diagnosis and monitoring.
Conclusions:
- While MRI has advanced MS evaluation, new questions arise about pathological interactions and remyelination.
- Longitudinal studies with large patient cohorts and diverse phenotypes are necessary to address these questions.
- Further research using advanced MRI is crucial for a comprehensive understanding and improved management of MS.
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